Pathology of Infections I

Question 1

describe the normal defenses to bacterial invasion and settings for invasion

Answer 1

Question 2

describe the spread of S. aureus

Answer 2

• skin infection:
  
  • folliculitis, furuncle, carbuncle, impetigo, cellulitis, multiple abscesses
• lymphatics
  
  • lymphadenitis (local, distant)
• venous:
  
  • (regional veins, thoracic ducts) → reach the major vena cava and right side of heart → right-sided valve (tricuspid, pulmonary) endocarditis

Question 3

S. aureus reach the lung through ____ and produce ____

Answer 3

S. aureus reach the lung through pulmonary artery and produce lung abscesses

Question 4

S. aureus travels through the pulmonary veins to reach the ____

Answer 4

S. aureus travels through the pulmonary veins to reach the left side of the heart (mitral, aortic valve), endocarditis

Question 5

describe bacteremia

Answer 5

Question 6

describe sepsis/septicemia

Answer 6

Question 7

describe direct tissue injury

Answer 7

• where cell death is induced by direct contact and entry (e.g. impetigo)

Question 8

describe exotoxins

Answer 8

Question 9

describe vascular damage

Answer 9

Question 10

describe indirect tissue injury

Answer 10

Question 11

which organism causes a polymorphonuclear leukocyte with exudate tissue response?

Answer 11

bacteria

Question 12

which organisms cause a tissue response with lymphocytes and macrophages?

Answer 12

viruses and intracellular organisms

Question 13

which organisms cause a tissue response with granulomatous inflammation?

Answer 13

tuberculosis/leprosy

Question 14

which organisms cause a tissue response with eosinophils?

Answer 14

parasites

Question 15

which organisms cause a tissue response with mixed PMNs, lymphocytes, macrophages and giant cells?

Answer 15

fungi

Question 16

which organisms cause a tissue response with fibrosis?

Answer 16

schistosoma

Question 17

which organisms cause a tissue response with pseudomembrane formation?

Answer 17

Diphtheria & Clostridium difficile

Question 18

which organisms cause a tissue response with necrosis (gas gangrene)?

Answer 18

Clostridia perferengies

Question 19

Answer 19

Question 20

Answer 20

Question 21

describe what is seen in the image

Answer 21

Question 23

S. mansoni and S. japonicum affect _____

Answer 23

S. mansoni and S. japonicum affect the liver (hepatomegaly with portal hypertension)

Question 24

S. hematopium affects _____

Answer 24

S. hematopium affects the bladder (bladder cancer)