wk 3 biochem recap

Question 1

where does fatty-acyl-CoA synthesis and activation occur

Answer 1

in cytoplasm

Question 2

what allows fatty-acyl-CoA to be transported across membrane

Answer 2

carnitine

Question 3

fatty acyl-CoA is converted to acetyl-CoA via

Answer 3

beta oxidation

Question 4

malonyl CoA is

Answer 4

a precursor for fatty acyl-CoA (comes from citrate)

Question 5

t/f lipids contain phosphate groups carbohys, proteins

Answer 5

true

Question 6

fatty acids can be used in gluconeogenesis t/f

Answer 6

false

Question 7

fatty acids have to be activated to acetyl-CoA

Answer 7

false

activated to acyl-CoA

Question 8

where does beta oxidation occur (LIKELYQ)

Answer 8

mitochondrial matrix

Question 9

products of beta oxidation (LIKELY Q)

Answer 9

1 acetyl-coa
1 FADh2
1 NAHD + H+
1 fatty acyl-CoA shortened by 2 carbons

Question 10

number of cycles calculated by (LIKELYQ)

Answer 10

cycles= (no. of Carbon/2) - 1

Question 11

purpose of ketone bodies in peripheral tissue

Answer 11

energy metabolism for brain/heart/renal under fasting conditions

Question 12

where are ketone bodies formed

Answer 12

liver mitochondria (hypoglycaemia)

Question 13

3 ketone bodies (LIKELYQ)

Answer 13

acetoacetate
alpha-3-hydroxy-butyrate
acetone

Question 14

t/f ketone can lead to ketoacidosis

Answer 14

true

Question 15

t/f ketone accumulates as a by-product of beta oxidation

Answer 15

true

under starved conditions

Question 16

cofators for synthesis of fatty acids

Answer 16

NADPH

Question 17

t/f there is alength consteain in fatty acid synthesis

Answer 17

true

stops at C-16

Question 18

t/f AMP, gucagon, epinephrine inhibit acetyl CoA carboxylase activity

Answer 18

true

Question 19

what is abundant when fatty acids in excess

Answer 19

palmitoyl CoA (inhibitis acetyl coA carboxyase

Question 20

t/f if citrate stimulates aoollestericlly, then citrate helps insulin to stimualte the catalytic activity of acetyl-coA carboxylase

Answer 20

false

Question 21

urea is synthesised from gaining 2 nitrogens. Where are both obtained

Answer 21

free ammonium

aspartic acid

Question 22

t/f carbon skeletons of all amino acids can enter TCA

Answer 22

true

Question 23

t/f removal of mino group only ooccurs in liver cells for amino acid catabolism

Answer 23

false

Question 24

glucose travelled in blood via

Answer 24

GLUT2

Question 25

glucose-6-phosphatase is used to catalyse

Answer 25

glucose-6-p to glucose

Question 26

t/f gluconeogenesis is the reveral of glycolyss

Answer 26

false

Question 27

glycogen is a polymer. what catalyst which allows 4 glucose molcules to bind

Answer 27

glycogenin protein

Question 28

t/f glycogenin is rate limiting for glycogen production

Answer 28

true

can only join 4, glycogen synthase then required to join more glucose

Question 29

t/f amino acids can serve as precursors for gluconeogenis

Answer 29

true

oxaloacetate

Question 30

t/f glucose has to be bound to UDP before transferred onto glycogen

Answer 30

true

Question 31

t/f glucose removws from glycogen as glucose-6-p

Answer 31

false

first phosphorylates as glucose-1-phosphate