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FND4 > Drug Class MOAs > Flashcards

Drug Class MOAs Flashcards

1
Q

Triptans

A

5HT1B/D-selective serotonin receptor AGONIST

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2
Q

Triptan Physiological Action

A

Vasoconstriction in cranial arteries

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3
Q

Triptan Clinical use

A

ACUTE Migraine and Cluster Headaches

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4
Q

Triptan Side Effects

A

DROWSINESS
NAUSEA
VOMITING

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5
Q

Sumatriptan ROA with the shortest Onset of action?

A

SubQ

10 Minutes

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6
Q

Sumatriptan side effect with intranasal ROA?

A

DYSGEUSIA

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7
Q

SubQ ROA Side effect?

A

Tingling sensation

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8
Q

Location of Serotonin Receptor: 5HT1 Gi GPCR

A

Brainstem, Basal Ganglia, Cranial Blood Vessels

Remember its Gi

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9
Q

Location of Serotonin Receptor: 5HT3 Na+ channel

A

“Neuronal” Area postrema NTS Emetic reflex

Remember its a ligand gated Na+

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10
Q

Ergot Alkaloids are used for….

A

Severe headache, migraine, cluster headache, prevent hemorrhage, One drug used for parkinsons

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11
Q

Properties of Ergot Alkaloids

A

Oxytocic
Emetic
Multi-MOA receptor subtypes

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12
Q

Common side effects for Ergot Alkaloids

A

PHYSIOLOGICAL DEPENDENCE with long-time use causing rebound headaches

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13
Q

Uncommon but severe Ergot Alkaloid side effect

A

UNCONTROLLED VASOCONSTRICTION–>GANGRENE

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14
Q

Dihydroergotamine

A

Migranal

AGONIST 5HT1/2, alpha1/2 adrenergic, D2/D3 Dopamine receptors

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15
Q

Dihydroergotamine clinical use…

A

PERSISTENT MIGRAINE >72HOURS

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16
Q

Bromocriptine

A

Cycloset, Parlodel

AGONIST D2 DOPAMINE RECPTOR

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17
Q

Bromocriptine clinical use

A

Ergot Alkaloid that is 4th line parkinsons therapy!!

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18
Q

Bromocriptine rare side effect…

A

Amnesia

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19
Q

Ergotamine

A

Ergomar

MIXED PARTIAL AGONIST/ANTAGONIST, 5HT, alpha adrenregic and dopamine receptors, and NE reuptake inhibitor

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20
Q

Ergotamine Clinical Usage…

A

ONLY ONE USED FOR VASCULAR HEADACHE

-NOT MIGRAINE

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21
Q

Methylergonovine

A

Methergine

ANTAGONIST D1 DOPAMINE RECEPTOR

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22
Q

Clinical Use of Methylergonovine….

A

Prevents hemorrhage during labor

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23
Q

Ergot Alkaloid that isn’t used to treat headaches….

A

Methylergonovine

24
Q

The chemotrigger zone is located in the….

A

area postrema, which controls vomiting

25
Q

What receptors are present in the area postrema and what do they do?

A

D2 dopamine receptors, activate vomiting centers (CAUSE THE EMESIS)

26
Q

What do 5HT3 antagonists do?

A

Block the serotonin on vagal nerve terminals and in CTZ (chemoreceptor trigger zone)**

27
Q

Anti-emetics have what type of MOA?

A

They are 5HT3 or Dopamine receptor antagonists

28
Q

Chlopromazine

A

Thorazine

  • Dopamine receptor antagonist
  • Typical*
29
Q

Ondansetron

A

Zofran

  • Setron
  • 5HT3 ser receptor antagonist
30
Q

Side effects of Ondansetron….

A

Headache, constipation, drowsiness

31
Q

Anti-Emetic drug recommended for Irritable Bowel Syndrome….

A

Alosetron (Lotronex)

32
Q

Alosetron

A

Lotronex

-5HT3 antagonist

33
Q

Pharmacologic Action for Sympathetic Amine Anorectic Agents

A

Suppress appetite by increasing NE and DA release and OR reuptake

34
Q

Phentermine

A

Adipex

  • NE and DA releaser and reuptake inhibitor
  • methamphetamine analog*
35
Q

Serious side effect of phentermine

A

Cadiac valvopathy and pulmonary hypertension, especially with FEN FEN

36
Q

Benzphetamine

A

Didrex, Regimex

-metabolizes to verious amphetamines stimulate MOA release from vesicle storage

37
Q

Side effects of Benzphetamine….

A

High abuse potential

Significant behavioral change

38
Q

Non-Amphetamine Sympathomimetic Amines..

A

Phendimetrazine

Diethylproprion*

39
Q

Longest acting Sympathomimetic Amine…

A

Diethylproprion

40
Q

Diethylpropion

A

Tenuate

-Similar to amphetamine but LESS ABUSE POTENTIAL

41
Q

Which weight loss aid can you use the longest?

A

Diethylpropion (Tenuate)

42
Q

Loraserin

A

Belviq

  • NOT a sympathetic amine but modulates appetite via MOA signaling
  • 5HT2C receptor AGONIST*
43
Q

Side effect most important to monitor with Loraserin…

A

SEROTONIN SYDROME

44
Q

Drugs of abuse activate what pathway….

A

Mesolimbic Dopamine Pathway

Ventral tegmental area dopamine neurons that project to the nucleas accumbens

45
Q

Modafinil

A

Provigil

  • Undetermined, but associated with an increase in brain DA by blocking DA transporters
  • Addicitve potential
46
Q

Clinical use of Modafinil…

A

NARCOLEPSY

47
Q

Armodafinil

A

Nuvigil

  • Undetermined, but associated with an increase in brain DA by blocking DA transporters
  • Addicitve potential
48
Q

Clinical use of Armodafinil

A

NARCOLEPSY

49
Q

Canniboid Receptor Agonists mimic…

A

Delta-9-Tetrahydrocannabinol (THC)

50
Q

CB1 Receptors

A

Brain, Detox, Sex

-hippocampus (etc), reporucctive organs, liver

51
Q

CB2 receptor

A

Immune System & Pain

-T&B lymphocytes, nerve terminals

52
Q

Reasons for discontinuation of Cannabinoid receptor agonists…

A

Increase heart rate and psychological effects like AFFECTIVE euphoria and easy laughter

53
Q

Dronabinol

A

Marinol, Syndros

Oral THC synthetics
-CB1/2 cannabinoid receptor agonist

54
Q

Nabilone

A

Cesamet

Oral THC Synthetics
CB1-selective* cannabinoid receptor agonist

55
Q

Clinical use for Nabilone…

A

REFRACTORY (CHEMO INDUCED) NAUSEA AND VOMITTING

56
Q

Location of 5HT2…

A

Bronchiols, Uterine, Intestine

Gq

57
Q

Location of 5HT4-7…

A

Gut, Hippocampus, Smooth Muscle

Gs

FND4 (6 decks)

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