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FND4 > Monoamine 2 > Flashcards

Monoamine 2 Flashcards

1
Q

Dobutamine acts on what receptor?

A

Beta 1

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2
Q

Dobutamine

A

Dobutrex

Beta 1 Agonist
Increases heart rate, cardiac output

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3
Q

Terbutaline acts at what receptor?

A

B2

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4
Q

Terbutaline

A

Brethine

-Beta 2 selective agonist

Relaxes bronchial, uterine smooth muscle
For acute bronchospasms

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5
Q

ONLY BETA 3 AGONIST

A

Mirabegron

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6
Q

Mirabegron

A

Myrbetriq

B3 selective Agonist

RELAXES BLADDER(THE DETRUSOR MUSCLE)

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7
Q

Mirabegron is used for what?

A

Overactive Bladder

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8
Q

ROA for Beta 2 Agonist

A

INHALED

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9
Q

1st Line therapy for bronchospasm associated with obstructive airway disease…

A

SABAs and LABAs

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10
Q

Short acting Beta Agonist Properties…

A

SABAs

  • Rapid Onset of Action
  • Short Duration of Action
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11
Q

Clinical Use of SABAs….

A

Acute bronchospasms

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12
Q

Long Acting Beta Agonists Properties….

A

LABAs

  • Slow Onset of Action
  • Long Duration of Action
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13
Q

Clinical Use of LABAs…

A

Bronchospasm Prophylaxis

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14
Q

Albuterol

A

ProAir, Ventalin, Proventil

SABA

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15
Q

Salmeterol

A

Serevent Diskus

LABA

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16
Q

Atenolol

A

Tenormin

Clinical uses, migraine Prophylaxis and Essential tremor, HTN, everything

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17
Q

Metroprolol

A

Toprol, Lopressor

B1 beta blocker

Everything but HR control

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18
Q

Bisoprolol

A

Zebeta

B1 beta blocker

HTN

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19
Q

Nebivolol

A

Bystolic

B1 Beta Blocker

Migraine, HTN

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20
Q

Propanolol

A

Inderal

Non selective beta blocker

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21
Q

Carvedilol

A

Coreg

Non selective Beta + A1 agonist

HTN

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22
Q

Labetalol

A

Trandate, Normodyne

Non Selective Beta + A1 agonist

HTN

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23
Q

Beta 2 Agonist Common side effects…..

A

Tachycardia
TREMOR
CNS STIMULATION

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24
Q

Beta Blocker Common Side Effects….

A

Bradycardia
CNS DEPRESSION
HYPOTENSION
Sexual dysfunction

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25
Q

MOA degrades Dopamine, leaving what metabolite….

A

DOPAC

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26
Q

D1-like GPCR…

A

Gs

D1 & D5

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27
Q

D1 receptors located….

A

Striatum
Olfactory
Renal NS
Enteric NS

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28
Q

D5 receptors located….

A

Limbic System
Hypothalamus
Vasculature
Heart

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29
Q

D2 like GPCR….

A

D2, D3, D4

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30
Q

D2 receptors located…

A 
Striatum
Substantia Nigra
Pituitary Gland
Renal NS
Vasculature
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31
Q

D3 receptors located….

A

Striatum
Olfactory Tubercle
Hypothalamus

32
Q

D4 receptors located….

A

Frontal Cortex
Substantia Nigra
Medulla*
MIdbrain*

33
Q

Serotonin Synthesis Steps…..

A

Tryptophan-> TPH–>5HTP–>AADC–>Serotonin

34
Q

Serotonin is metabolized by….

A

MAO

35
Q

5HT1 Gi GPCR location….

A

Brainstem
Basal Ganglia
Cranial Blood vessels

36
Q

5HT3 Gq GPCR location

A 
Na+ Channel
*ONLY LIGAND GATED*
"Neuronal"  
Area postrema 
NTS
Emetic Reflex
37
Q

Dopamine is synthesized in….

A

Midbrain:
Substantia Nigra
VTA

Hypothalamus

38
Q

Dopamine from Substantia Nigra is transported to

A

Nigrostriatal (Doral) Striatum

39
Q

Dopamine from VTA is transported to

A

Mesolimbic (Ventral) striatum

40
Q

Dopamine from Hypothalamus is transported to

A

Tuberoinfundibular Pituitary Gland

41
Q

Parkinson’s disease displays the degeneration of what pathway?

A

Nigrostriatal

(dorsal) Striatum

42
Q

Serotonin is synthesized where?

A

Raphe Nucleus

43
Q

Serotonin synthesized in the Rostral (RN) are transported…

A

Forebrain
Limbic System
Basal Ganglia

44
Q

Serotonin synthesized in the Caudal (RN) are transported….

A

Cerebellum

Spinal Cord

45
Q

Goal of Dopamine D2 and D3 receptor agonists…

A

Delay need for L-Dopa therapy

46
Q

D2,D3 agonists are used for

A

Parkinsons Disease

47
Q

Ropinirole

A

Requip

D3>D2 agonist

48
Q

Pramipexole

A

Mirapex

D3>D2 agonist

49
Q

Rotigotine

A

Neupro

also has affinity for D1

50
Q

Parkinsons Disease Gold standard therapy is…

A

Levodpa and Carbidopa

51
Q

Levodopa + Carbidopa

A

Duopa, Rytary, Parcopa, SINEMET*

combination therapy allows lower levodopa and associated with less side effects.

52
Q

PD symptoms that respond to Levodopa…

A

Tremor, bradykinesia, hypomimia, etc.

53
Q

Carbidopa works how?

A

AADC inhibitor used to inhibit peripheral conversion of Ldopa to dopamine

54
Q

Carbidopa helps levodopa how?

A

Without it only 1% of Ldopa would cross BBB

55
Q

Irreversible MAO-B isoform selective inhibitors goal…

A

nigrostriatal pathway degeneration by targetin more DA selective MAO isoform

56
Q

Selegiline

A

Carbex, Eldepryl, EMSAM, Zelapar

*METABOLIZED TO 3 ACTIVE METABOLITES: desmethylselegeline and Levoamphetamine and Levomethamphetamine**

57
Q

Rasagiline

A

Azilect

5 times more potent than Selegiline

58
Q

Entacapone

A

Comtan

REVERSIBLE COMT INHIBITORS (PERIPHERAL)

59
Q

Tolcapone

A

Tasmar

PERIPHERAL AND CENTRAL REVERSIBLE COMT INHIBITOR

60
Q

Entacapone side effect

A

Rhabdomyolysis with urine discoloration

61
Q

Tolcapone side effect

A

drug induced hepatotoxicity

62
Q

Antipsychotics target….

A

Positive Symptoms

63
Q

Positive Symptoms of psychosis….

A

Hallucinations
Delusions
Disorganized thinking or behavior
Attentional Deficits

64
Q

Pototypical Antipsychotic 1st generation

A

Chlorpromazine

65
Q

Chlorpromazine

A

Thorazine

Low potency, 1st generation
-D2 receptor antagonist

66
Q

antipsychotics target dopamine in the…..

A

Limbic sytem and the striatum to treat ++symptoms

67
Q

Prototypical second generation AP…..

A

Clozapine

68
Q

Clozapine

A

Clozaril

D2 dopamine and 5HT2 antagonist

NO TARDIVE DYKINESIA

69
Q

Second generation are less prone to……

A

EPS AND TARDIVE DYSKINESIA

70
Q

Haloperidol

A

Haldol

High potency first gen AP

71
Q

Olanzapine

A

Zyprexa

2nd gen AP

72
Q

Risperidone

A

Risperdal

2nd gen AP

73
Q

Quetiapine

A

Seroquel

2nd gen AP

74
Q

Ziprasidone

A

Geodon

2nd gen AP

75
Q

Aripiprazole

A

Abilify

2nd gen AP

76
Q

Lurasidone

A

Latuda

2ndGen AP

FND4 (6 decks)

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