Multiple Meyeloma

Question 1

A ‘monoclonal gammopathy’ a malignancy of antibody producing plasma cells

Answer 1

Multiple Myeloma

Question 2

Multiple Myeloma is called a gammopathy because the ‘gamma band’ of serum proteins, after separation by electrophoresis, contains the

Answer 2

Immunoglobulins

Question 3

Multiple myeloma: Multiple because by the time the condition is dectected, multiple foci of tumor cells are

Answer 3

Present

Question 4

Multiple myeloma: Myeloma because tumors form in the

Answer 4

Bone marrow

Question 5

Plasma cell tumors that begin with a single cell

Answer 5

Monoclonal gammopathies

Question 6

All cells of a monoclonal gammopathy tumor secrete antibody of the same

Answer 6

Isotype

Question 7

The secreted antibody in a monoclonal gammopathy is the

Answer 7

Paraprotein

Question 8

Multiple myeloma has many clumps of

Answer 8

Tumor cells

Question 9

Erodes bone via stimulation of osteoclasts

Answer 9

Multiple Myeloma

Question 10

Extramedullary – less mature B cell, secretes IgM, less bone marrow involvement

Answer 10

Waldenstrom’s macroglobulinemia

Question 11

Only the heavy chain is secreted in

Answer 11

Heavy-chain disease

Question 12

Only the light chains are secreted in

Answer 12

Light-chain disease

Question 13

Light chains in in urine are

Answer 13

Bence-Jones Proteins

Question 14

In serum electrophoresis, antibodies are mostly in the

Answer 14

Gamma band

Question 15

The gamma band is elevated in

Answer 15

Multiple Myeloma

Question 16

Gamma globulin = partially purified

Answer 16

Antibodies

Question 17

Elevated gamma region in electrophoresis is the “M spike” for

Answer 17

Myeloma

Question 18

Does not show which isotype is elevated

Answer 18

Serum electrophoresis

Question 19

Determines which isotype is elevated

Answer 19

Immunofixation

Question 20

Separate proteins on cellulose acetate strips.

-Flood a strip with antibodies to a specific human isotype

Answer 20

Immunofixation

Question 21

In immunofixation, if antibody binds to plasma protein on strip, we see formation of a

Answer 21

Precipitate

Question 22

A single type of light chain and a single type of heavy chain should be elevated in

Answer 22

Multiple Myeloma

Question 23

In Immunofixation, the antibody to whole serum that binds all serum proteins is labeled as

Answer 23

S

Question 24

Large oval cells with relatively uncondensed nuclei

Answer 24

Plasma cells

Question 25

In a plasma cell slide, the blue cytoplasm represents extensive

Answer 25

Rough ER

Question 26

In multiple myeloma, we see erosion of bone and

Answer 26

Hypercalcemia