Quiz 7 - Granger - Malaria Flashcards
The pathogen in malaria is what?
Protozoan
- Mosquito transmission
- Anopheles
*Single host is: humans
Malaria is associated with what environment?
Swampy areas
-Mal-Air
T/F - Malaria infection can be lethal.
TRUE
Malignant (dangerous) malaria is from what species?
Anopheles spp.
-Plasmodium falciparum
Who is at risk for death from malaria?
6 months to 6 years
Non-immune adults
Pregnant women
Emigrants returning from home visits
US cases of malaria?
1727 in 2013
Severe malaria occurs in?
Sickle cell trait in children
Denizens of endemic areas
Look up life cycle of malaria
Do it
Knob structures in RBCs are found with what spp.?
Plasmodium falciparum
-These are very, very lethal, like 100% lethal
What are the benefits to the parasite of sequestration?
Evade spleen clearance
Low pH that favors replication
-Also, high pCO2
Leads to enormous parasite mass in severe malaria
T/F - Severe malaria is distinct form septic shock.
TRUE
What is the triad of malaria lethality?
Acidosis
Coma
Anemia
T/F - Affected tissues may not present symptoms and signs.
TRUE
What are the two main sites of sequestration?
Others?
- Brain
- Retina
Others:
- Mesentery
- Viscera
What is the three pronged approach for combating malaria in the world?
Insecticide impregnated bed nets
Residual insecticide spraying
Pre-emotive tx with ACT
-ACT - Artemisinin-based combo therapy)
Cost?
- Philanthropists
- Lack of acquired immunity in increasingly older individuals
