Gq

Question 1

Q for

Answer 1

quirky

Question 2

type of pathway Gs and Gi are are part of

Answer 2

cAMP dependent

Question 3

Gq is part of which pathway

Answer 3

phospholipase c dependent pathway

Question 4

pathway

Answer 4

1. noradrenaline binds to alpha 1 recepto
2. alpha subunit is activated when GTP binds and it dissociates from the beta-gamma complex
3. Then alpha activates PLC
4. PLC hydrolyses PIP2 to IP3 and DAG
5. IP3 causes calcium to be released by binding to SR
6. DAG activates PKC
7. Calcium binds to calmodulin, which activates MLCK
8. MLCK phosphorylates MLC
9. causing a conformational change in myosin
10. cross bridges can form and therefore contraction occurs

Question 5

receptors

Answer 5

M1, M3, M5 (odd numbered), alpha 1adrenoreceptor, angiotensin 11 receptor, vasopressin 1

Question 6

M1 (muscarinic ACh)

Answer 6

excitatory

• CNS
• gastric acid secretion

Question 7

M3 (muscarinic ACh)

Answer 7

excitatory

• secretion from glands
• smooth muscle contract of urinary tract
• vasodilation by NO (vascular system)

Question 8

M5

Answer 8

CNS- memory, arousal, attention analgesia

Question 9

alpha 1 adrenoreceptor

Answer 9

• vasoconstriction

- increase in BP