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Sketchy Pharm-Cardio > Antihypertensives > Flashcards

Antihypertensives Flashcards

1
Q

What type of calcium channels do CCBs attach to?

A

L type calcium channels

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2
Q

Dihydropyridines block L type channels on what cells?

A

Smooth muscle cells

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3
Q

Non-dihydropyridines block L type channels on what cells?

A

Cardiac muscle cells

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4
Q

What are the two types of CCBs?

A

DHP

NDHP

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5
Q

DHP MOA?

A

DHPs block L type receptors on smooth muscle cells causing vasodilation

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6
Q

DHPs have what name?

A

-dipine

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7
Q

NDHP MOA?

A

NDHPs block L type calcium channels on cardiac muscle cells resulting in decreased contractility

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8
Q

NDHPs have what name?

A

Verapamil

Diltiazem

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9
Q

What nodes do NDHPs exert their effects on?

A

AV and SA

Decreased HR

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10
Q

CCBs treat?

A

Hypertension
Hypertensive emergency
Stable angina
Prinzmetal angina

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11
Q

What CCB treats hypertensive emergency in pregnancy?

A

Nifedipine

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12
Q

DHP effects on afterload?

A

DHPs dilate coronary arteries resulting in decreased afterload

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13
Q

DHP adverse effects?

A

Light headedness
Headache
Peripheral edema
Reflex tachycardia

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14
Q

NDHP contraindications?

A

Patients with heart block

Beta-blockers

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15
Q

Primary HTN treatment?

A

Hydrochlorothiazide
CCB
ACE-I

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16
Q

HTN emergency treatment?

A 
Beta-1 antagonists
Labetalol
CCBs
Hydralazine
Nitrate
Nitroprusside
Fenoldopam
17
Q

Labetalol MOA

A

Beta and Alpha antagonist

18
Q

Hydralazine treatment issue?

A

Induce reflex tachycardia and worsen angina so administer with beta-blocker to reduce SNS response

19
Q

Nitroprusside MOA

A

Production of NO causes increased cGMP, relaxing smooth muscle, and causing vasodilation

20
Q

Nitroprusside adverse

A

cyanide poisoning

21
Q

Fenoldopam MOA

A

D1 agonist causing increased cAMP resulting in arterial dilation

Sketchy Pharm-Cardio (4 decks)

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