Transfusion Reactions

Question 1

Transfusion reaction due to recipient anti-IgA IgG Abs (due to IgA deficiency)

Name and time range?

Answer 1

Anaphylactic

(within a few seconds to minutes)

Question 2

Transfusion reaction due to ABO incompatibility; can progress to renal failure

Name and time range?

Answer 2

AHTR

(Acute hemolytic transfusion reaction)

Question 3

The most common blood transfusion reaction

Answer 3

Febrile nonhemolytic

(2/2 cytokine accumulation during blood storage) Within 1-6 hours

Question 4

Transfusion reaction due to recipient IgE Abs & mast cell activation

Answer 4

Urticarial/Allergic

(within 2-3 hours)

Question 5

Transfusion reaction due to donor anti-leukocyte Abs

Answer 5

TRALI

(Transfusion-related Acute Lung Injury) Within 6 hours

Question 6

Transfusion reaction due to anamnestic Ab response

(reaction to a familiar antigen)

Answer 6

Delayed hemolytic

(2-10d)

Question 7

Transfusion reaction due to cytokine accumulation during blood storage

Answer 7

Febrile nonhemolytic

(within 1-6 hours)

• Most common transfusion reaction