08 - Nervous system

Question 1

Large granular body found in neurons. These granules are of rough endoplasmic reticulum (RER) with rosettes of free ribosomes, and are the site of protein synthesis.

Answer 1

Nissl body

Question 2

This refers to the dissolution o f the Nissl bodies in the neuron and the loss of cytoplasmic basophilia

Answer 2

chromatolysis

Question 3

Identify: the cell body of a neuron (containing the nucleus)

Answer 3

perikaryon

Question 4

Steps of neuronal regeneration

Answer 4

1. Changes in the Perikaryon
2. Degeneration of the distal axonal segment
3. Regeneration of the proximal axonal segment

Question 5

Refers to the degeneration of the distal axonal segment

Answer 5

Wallerian degeneration (a.k.a. anterograde degeneration)

Question 6

Identify: CNS mononuclear phagocyte

Answer 6

microglia

Question 7

Cells in the CNS that are neither neurons nor microglia

Answer 7

macroglia

Question 8

Two types of macroglia and their functions

Answer 8

Astrocytes - nutrition and support

Oligodendrocytes - source of myelin

Question 9

These cells line the ventricles and secrete CSF

Answer 9

ependymal cells

Question 10

source of myelin in the CNS

Answer 10

oligodendrocytes

Question 11

source of myelin in the PNS

Answer 11

Schwann cells

Question 12

Disease: immune-mediated destruction of oligodendrocytes

Answer 12

multiple sclerosis

Question 13

Disease: immune-mediated destruction of Schwann cells

Answer 13

Guillain-Barre syndrome

Question 14

Infection with this microorganism is associated with Guillain-Barre syndrome

Answer 14

Campylobacter jejuni

Question 15

Most critical event in the regeneration of a peripheral nerve

Answer 15

proliferation of schwann cells