7.1.2: Gastric disease - diagnosis, treatment and management Flashcards

1
Q

1

A

Dorsal squamous fundus

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2
Q

2

A

Greater curvature

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3
Q

3

A

Margo plicatus

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4
Q

4

A

Lesser curvature

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5
Q

5

A

Cardia

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6
Q

6

A

Ventral glandular fundus

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7
Q

7

A

Antrum

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8
Q

8

A

Pylorus

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9
Q

Risk factors for gastric disease

A
  • Lack of access to forage
  • Lack of access to water
  • High carbohydrate diets -> these have acidifying effects on gastric juices
  • High stress environments/individuals
  • Other focuses of pain (sometimes can’t resolve gastric disease until pain from elsewhere in the body is controlled)
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10
Q

Clinical signs of gastric disease

A
  • Colic signs (particularly after eating)
  • Weight loss
  • Bucking/rearing under saddle
  • Resentment of girthing and leg aid
  • Poor performance
  • Changes in temperament
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11
Q

Preparation of a patient for gastroscopy

A
  • Withhold food for at least 12hrs; some centres say longer (need empty stomach to properly assess)
  • Water should be removed ~4hrs before
  • Use a grazing muzzle for horses liable to eat their own bedding/faeces in order to prevent this happening
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12
Q

What would you use to sedate a horse for gastroscopy?

A

Detomidine + butorphanol

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13
Q

How do you grade squamous ulceration visualised on gastroscopy?

A
  • Grade 0 - epithelium intact, no appearance of hyperkeratosis
  • Grade I - the mucosa is intact but there are areas of hyperkeratotis
  • Grade II - small single or multifocal lesions
  • Grade III - large single or extensive superficial lesions
  • Grade IV - extensive lesions with areas of apparent deep ulceration
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14
Q

Which grade of squamous ulceration is shown here?

A

Grade 0

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15
Q

Which grade of squamous ulceration is shown here?

A

Grade IV

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16
Q

How do we describe glandular disease lesions?

A
  • Mild/moderate/severe
  • Focal/multifocal/diffuse
  • Raised/flat/depressed
  • Hyperaemic/haemorrhagic/fibrinosuppurative

Any combination is possible. Some centres also use diagrams to note the appearance of lesions.

Numerical grading systems are no longer used for glandular disease.

17
Q

First line treatment of gastric disease

A
  • Oral omeprazole -> for squamous ulceration. Licensed and effective. Better bioavailability if horse starved beforehand.
  • Misoprostol -> for glandular disease
  • Not uncommon to see combination therapy
  • ± oral sucralfate as an adjunct to the above
18
Q

Which of the following is considered easier to treat?
a) glandular disease
b) squamous ulceration

A

b) squamous ulceration - typically takes 3 weeks to treat compared to 3 months for glandular disease

19
Q

1

A
20
Q

2

A
21
Q

3

A
22
Q

4

A
23
Q

How does oral sucralfate help with the treatment of gastric disease?

A

Oral sucralfate coats the stomach and helps to bolster the mucus barroer while we are treating the lesions with other drugs.

24
Q

How often should you endoscope a horse with gastric disease to monitor treatment progress?

A

Every 4 weeks

25
Q

True/false: once a horse has had one episode of glandular disease, they should forever be managed accordingly as they are at a high risk of recurrence.

A

True

These horses are like laminitic ponies - highly predisposed to recurrence.

26
Q

Husbandry changes you would implement for long-term management of gastric diseases

A
  • Feed roughage al lib throughout the day
  • Reducing stressful stimuli where at all possible
  • Elimination of carbohydrates from the horse’s diet; replace with oils if calories needed
  • Feed supplements: there is evidence for pectin and lecithin to bolster the mucus barrier
  • Can use oral omeprazole long-term at 1 mg/kg^ daily; ideally target this to high risk periods e.g. moving yards, competitions -> check competition rules to check if this is allowed

(^this is 1/4 of the therapeutic dose)