Chemotherapies Flashcards
What is the mechanism of action for alkylating agents?
Act directly on DNA to ultimately prevent cell division and cause cell death
Cross link DNA strands to prevent replication
Abnormal base pairing and DNA strand breaks
What are six types of alkylating agents?
Alkylsulfonates
Ethylenimines
Hydrazines and Triazines
Metal salts
Mustard gas derivatives
Nitrosureas
What is the mechanism of action for antimetabolites?
Structural analogs of naturally occuring metabolites that compete for catalytic or regulatory site of key enzyme.
Can also be substituted and incorporated into DNA and RNA
What are five types of antimetabolites?
Purine antagonists
Pyrimidine antagonists
Folate analogs
Adenosine analogs
Substituted ureas
What is the mechanism of action for topoisomerase inhibitors?
Inhibit or interfere with topoisomerase enzymes I and II
What are types of topoisomerase I inhibitors?
Irinotecan
Topotecan
What are types of topoisomerase II inhibitors?
Amsacrine
Etoposide
Teniposide
What is the mechanism of action for Anti-microtubule agents?
Block the ability of a cancer cell to divide via kinetic stabilization of microtubule dynamics
What are types of anti-microtubule agents?
Vinca alkaloids
Taxanes
Podophyllaotoxins
Camptothecin analogs
What is the mechanism of action for antitumor antibiotics?
Intercalate into DNa and prevent RNA synthesis
Maximal toxicity in S phase
What are types of antitumor antibiotics?
Anthracyclines
Chromomycins
Mitomycin and Bleomycin
What is the mechanism of action for monoclonal antibodies?
Attenuate hyperactive growth signals
Create immune response
Inhibit angiogenesis
What are the cell cycle specific drugs?
Antimetabolites
Topoisomerase I inhibitors
Antimicrotubule agents
Which drugs are not cell cycle specific?
Alkylating agents
Topoisomerase II inhibitors
Antitumor antibiotics
Monoclonal antibodies
