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USMLE 2019 > Patho > Flashcards

Patho Flashcards

1
Q

Rule of 10s of pheochromocytoma

A 
10% malignant
10% bilateral
10% extra-adrenal
10% calcify
10% kids
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2
Q

Hurthle cells

A

Hashimoto’s thyroiditis

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3
Q

thyroid disease assoc with increased risk of non-Hodgkin lymphoma

A

Hashimoto thyroiditis

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4
Q

most common cause of death in gigantism

A

cardiac failure

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5
Q

treatment of nephrogenic DI

A

Hydrochlorothiazide
Amiloride
Indomethacin

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6
Q

Aggressive correction of hyponatremia leads to

A

Central pontine myelinolysis

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7
Q

Paraneoplastic syndromes associated with small cell lung CA

A

ADH and ACTH

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8
Q

Treatment of SIADH

A

Vasopressin antagonists:
Tolvaptan
Conivaptan

Demeclocycline

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9
Q

most common cause of death among diabetics

A

myocardial infarction

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10
Q

rule of 1/3 of carcinoid syndrome

A

1/3 metastasize
1/3 present with second malignancy
1/3 are multiple

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11
Q

gastrin-secreting tumor of pancreas or duodenum

A

Zollinger-Ellison syndrome

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12
Q

recurrent diarrhea
cutaneous flushing
asthmatic wheezing
R-sided valvular disease

niacin deficiency
high urinary 5-HIAA

A

Carcinoid syndrome

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13
Q

MEN 1

Wermer syndrome

A

Pit Pan Para
Pituitary
Pancreas
Parathyroid

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14
Q

MEN 2A

Sipple syndrome

A

Pheochromocytoma
Parathyroid hyperplasia
Medullary thyroid carcinoma

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15
Q

MEN 2B

A

Oral / mucosal neuroma
Medullary thyroid carcinoma
Pheochromocytoma

*Marfinoid habitus

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16
Q

clinical syndrome of VIPoma (pancreatic tumor)

A

WDHA syndrome:
Watery Diarrhea
Hypokalemia
Achlorhydria

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17
Q

benign cystic tumor with germinal centers; second most common salivary gland tumor

A

Warthin tumor

papillary cystadenoma lymphomatosum

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18
Q

Triad of Plummer-Vinson syndrome

A

“Plummers DIG”
Dysphagia (esophageal webs)
IDA
Glossitis

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19
Q

CREST Syndrome of limited cutaneous systemic scleroderma

A 
Calcinosis cutis
Raynaud phenomenon
Esophageal dysmotility
Sclerodactyly
Telangiectasia
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20
Q

Risk factors for esophageal cancer

A 
AABCDEFFGH
Achalasia
Alcohol
Barrett
Cigarette
Diverticula
Esophageal web
Familial
Fat
GERD
Hot liquids
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21
Q

most common site of intestinal gastric adenoca

A

lesser curvature of stomach

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22
Q

Common symptoms of whipple disease

A

Foamy Whipped cream in a CAN
Cardiac
Arthralgia
Neurologic

foamy macrophages
PAS +
Tropheryma whipplei (gram +)

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23
Q

Diagnosis of celiac sprue

A

serum level of tissue transglutaminase antibodies

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24
Q

malabsorption syndrome assoc with dermatitis herpetiformis

A

celiac sprue

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25
Q

treatment of Crohn’s disease

A 
Corticosteroids
Azathioprine
Methotrexate
Infliximab
Adalimumab
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26
Q

treatment of ulcerative colitis

A

Sulfasalazine
6-mercaptopurine
Infliximab
Colectomy

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27
Q

most common congenital anomaly of the GIT

A

Meckel diverticulum

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28
Q

Five 2s of Meckel

A 
2% of population
2 inches long
2 feet from ileocecal valve
2 years old
2 types of epithelia (gastric/pancreatic)
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29
Q

Diagnosis of Meckel

A

Pertechnetate study

uptake by ectopic gastric mucosa

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30
Q

diagnosis of Hirschsprung

A

rectal suction biopsy

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31
Q

most common cause of small bowel obstruction

A

adhesions

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32
Q

causes of ileus

A

post op abdominal surgery
opiates
hypokalemia
sepsis

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33
Q

common location of ischemic colitis

A

splenic flexure

distal colon

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34
Q

most common non neoplastic polyp in the colon

A

hyperplastic

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35
Q

Failure of GnRH-secreting neurons to migrate from olfactory lobes to the hypothalamus

A

Kallmann’s syndrome

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36
Q

FAP
+
osseous and soft tissue tumors

congenital hypertrophy of RPE

A

Gardner syndrome

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37
Q

FAP
+
malignant CNS tumor

A

Turcot syndrome

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38
Q

molecular pathogenesis of colorectal carcinoma

A

loss of APC gene
K-RAS mutation
loss of tumor suppressor gene (p53)

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39
Q

serum marker that decreases in Wilson disease

A

ceruloplasmin

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40
Q

fatal childhood hepatoencephalopathy

mitochondrial abn
fatty liver
hypoglycemia
vomiting
hepatomegaly
coma
A

Reye syndrome

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41
Q

hobnail appearance of the liver

A

alcoholic cirrhosis

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42
Q

intracytoplasmic eosinophilic inclusions (Mallory bodies) are seen in

A

alcoholic hepatitis

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43
Q

aflatoxin: HCC

arsenic, vinyl chloride:

A

angiosarcoma

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44
Q

associated conditions with Budd-Chiari syndrome

A

hypercoagulable states
polycythemia vera
pregnancy
HCC

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45
Q

conjugated hyperbilirubinemia due to defective liver excretion; presents with grossly black liver

A

Dubin-Johnson syndrome

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46
Q

absent UDPGT leading to unconjugated hyperbilirubinemia; fatal within a few years

A

Crigler - Najjar syndrome type I

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47
Q

treatment of Wilson disease

A

penicillamine

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48
Q

Kayser - Fleischer rings

A

Wilson disease

hepatolenticular degeneration

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49
Q

symptoms of Wilson disease

A

Copper is Hella BAD

Ceruloplasmin low, Cirrhosis, Corneal deposits, Carcinoma hepatocellular
Hemolytic anemia
Basal ganglia degeneration
Asterixis
Dementia, Dyskinesia, Dysarthria
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50
Q

symptoms of hemochromatosis

A

“Can Cause Deposits”

Cirrhosis
CHF
Diabetes mellitus

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51
Q

autoimmune conditions associated with primary biliary cirrhosis

A

CREST
Sjogren
Rheumatoid arthritis
Celiac disease

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52
Q

unknown cause of concentric “onion skin” bile duct fibrosis

presents with alternating strictures and dilatation with beading of intra and extrahepatic bile ducts

A

Primary sclerosing cholangitis

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53
Q

migratory thrombophlebitis (Trousseau syndrome) seen in

A

pancreatic adenocarcinoma

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54
Q

obstructive jaundice with palpable, nontender gallbladder

A

Courvoisier sign in pancreatic adenocarcinoma

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55
Q

cause of isolated basophilia

A

myeloproliferative disease

CML

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56
Q

conditions decreasing ESR

A 
polycythemia
sickle cell disease
microcytosis
hypofibrinogenemia
CHF
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57
Q

Conditions assoc with basophilic stippling

A

BASically, ACiD Alcohol is LeThal

Anemia of chronic disease
Alcohol
Lead poisoning
Thalassemias

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58
Q

Conditions assoc with target cell

A

HALT

Hemoglobin C disease
Asplenia
Liver disease
Thalassemia

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59
Q

Conditions assoc with basophilic stippling

A

BASically, ACiD Alcohol is LeThal

Anemia of chronic disease
Alcohol
Lead poisoning
Thalassemias

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60
Q

Conditions assoc with target cell

A

HALT

Hemoglobin C disease
Asplenia
Liver disease
Thalassemia

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61
Q

treatment of sideroblastic anemia

A

pyridoxine

cofactor of ALA synthase

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62
Q

causes of sideroblastic anemia

A 
alcohol
lead
isoniazid
vit B6 def
copper def
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63
Q

anemia with elevated homocysteine and methylmalonic acid

A

Vit B12 deficiency

versus folate deficiency - normal methylmalonic acid

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64
Q

Nonmegaloblastic macrocytic anemias

A

liver disease
alcoholism
reticulocytosis
drugs (5-FU, zidovudine, hydroxyurea)

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65
Q

Heinz bodies

Bite cells

A

G6PD deficiency

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66
Q

Triad of PNH

A

Pancytopenia
veNous thrombosis
Hemolytic anemia

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67
Q 
Salmonella osteomyelitis
Dactylitis
Acute chest syndrome
Avascular necrosis
Stroke
Renal papillary necrosis

are complications of

A

Sickle cell disease

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68
Q

AIHA seen in Mycoplasma infections and infectious Mononucleosis

A

Cold agglutinin (IgM)

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69
Q

AIHA seen in Mycoplasma infections and infectious Mononucleosis

A

Cold agglutinin (IgM)

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70
Q

Schistocytes (helmet cells) are seen in

A

Macro and microangiopathic hemolytic anemias, thalassemias

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71
Q

Conditions causing eosinopenia

A

Cushing syndrome

Corticosteroids

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72
Q

Conditions causing lymphopenia

A

HIV
DiGeorge syndrome
Corticosteroids
SCID

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73
Q

Enzymes inhibited in lead poisoning

A

Ferrochelatase

ALA dehydratase

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74
Q

most common porphyria

A

porphyria cutanea tarda

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75
Q

5 Ps of Acute intermittent porphyria

A 
Painful abdomen
Port wine-colored urine
Polyneuropathy
Psychological disturbances
Precipitated by drugs, alcohol and starvation
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76
Q

Treatment of acute intermittent porphyria

A

Glucose
Heme

(to decrease activity of ALA synthase)

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77
Q

platelet disorder characterized by anti GpIIb/IIIa antibodies

may be triggered by viral illness

A

immune thrombocytopenia

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78
Q

platelet disorder characterized by deficiency of ADAMTS 13 (vWF metalloproteinase)

A

TTP

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79
Q

pentad of TTP

A 
FAT RN
Fever
Anemia (microangiopathic hemolytic)
Thrombocytopenia
Renal (Uremia)
Neurologic sx
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80
Q

most common inherited bleeding disorder

A

von Willebrand disease

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81
Q

Ristocetin cofactor assay is used in the diagnosis of

A

vWD (decreased agglutination)

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82
Q

Causes of DIC

A 
STOP Making New Thrombi
Sepsis (gram neg)
Trauma
OB complications
Pancreatitis
Malignancy
Nephrotic syndrome
Transfusion
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83
Q

decreased ability to inactivate factors V and VIII leading to thrombotic skin necrosis

may present with hemorrhage following administration of warfarin

A

protein C or S deficiency

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84
Q

Contents of cryoprecipitate

A 
Fibrinogen
vWF
Fibronectin
Factor 8
Factor 13
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85
Q

Blood transfusion risks (electrolyte imbalance)

A

Hypocalcemia

Hyperkalemia

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86
Q

S/Sx of Parkinson Disease

A 
SMART
Shuffling gait
Mask-like facies
Akinesia/bradykinesia
Rigidity
Tremors (resting)
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87
Q

disease characterized by bone pain, deformity and hearing loss

increased abnormal osteoclasts - multinucleated cells (100 nuclei)

A

Paget’s disease of the bone

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88
Q

most common cause of male hypogonadism

A

Klinefelter syndrome

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89
Q 
primary hypogonadism
long lower extremities
small, firm testes
azoospermia
intellectual disability
gynecomastia
sparse body hair
A

Klinefelter syndrome

47 XXY

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90
Q

Arm span > height
Long fingers
Joint laxity

A

Marfanoid habitus

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91
Q

gross:

well-defined yellowish tumors of adrenal cortex

A

adrenocortical adenomas

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92
Q

electrolyte imbalance in Conn’s syndrome

A

hypokalemia, metab alka

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93
Q

T cell NHL

A

Adult T cell lymphoma

Mycosis fungoides / Sezary syndrome

94
Q

lymphoma caused by HTLV-1

A

Adult T cell lymphoma (NHL)

95
Q

high serum level of 17-hydroxyprogesterone is diagnostic of

A

21-hydroxylase deficiency

congenital adrenal hyperplasia

96
Q 
rapid linear growth
weight gain
excessive sweating
oily skin
prognathism (protrusion of jaw)
thickened calvarium
large hands and feet
A

Gigantism

Acromegaly

97
Q

type of urethral injury presenting with high-riding prostate

A

posterior urethral injury

membranous urethra

98
Q

impaired tail mobility of the sperm (ciliary dyskinesia) leading to infertility

A

Kartagener syndrome

99
Q

Streak ovary
Short stature
Shield chest (bicuspid aortic valve, preductal CoA - notched ribs)
Lymphatic defects (webbed neck, cystic hygroma, lymphedema)
Horseshoe kidney

A

Turner syndrome

45 XO

100
Q

most common form of male pseudohermaphroditism

A

androgen insensitivity syndrome (testicular feminization)

101
Q

condition resulting to female pseudohermaphroditism

A

CAH

102
Q

autosomal recessive dso of sexual devt leading to ambiguous genitalia until puberty

A

5a reductase deficiency

103
Q

referred pain in the shoulder due to peritoneal irritation, most likely splenic laceration

A

Kehr’s sign

104
Q

gallstone ileus (stones >2.5cm) typically lodges in

A

ileum (narrowest portion of intestine)

105
Q

most common intra abdominal organ injured during blunt trauma

A

spleen

106
Q

conditions causing polyhydramnios

A 
esophageal / duodenal atresia
anencephaly
maternal DM
fetal anemia
multiple gestation
107
Q

most common ovarian tumor in the young (10-30 y/o)

A

Mature cystic teratoma

(dermoid cyst)

108
Q

ovarian neoplasm with uniform “fried egg” cells appearance on histology

A

Dysgerminoma

GCT

109
Q

large cells in the breast epidermis with clear halo suggesting an underlying DCIS

A

Paget cells

110
Q

Peau d’orange is usually seen in this type of breast malignancy

A

Inflammatory breast CA

111
Q

most common cause of scrotal enlargement in adult males

A

varicocele

112
Q

most common testicular tumor

A

seminoma

113
Q

most common testicular tumor in young boys (<3 y/o)

A

endodermal sinus tumor / yolk sac tumor

114
Q

most common testicular tumor in older men

A

testicular lymphoma

115
Q

tunica vaginalis lesion presenting as a testicular mass due to dilated epididymal duct

A

spermatocele

116
Q

premalignant lesion presenting as leukoplakia in penile shaft

A

Bowen disease

117
Q

most common extragonadal GCT in infants and young children

A

sacrococcygeal teratoma

118
Q

pancreatic tumor presenting with diarrhea, cholelithiasis and DM

A

somatostatin-producing tumor

119
Q

in lactase deficiency, stool pH is decreased (<6) because lactose is fermented by bacteria into:

A

short chain fatty acids:
acetate
butyrate
propionate

120
Q

constitutive activation of fibroblast growth factor receptor 3

A

achondroplasia

inhibition of chondrocyte proliferation

121
Q

most common site of osteonecrosis

A

femoral head

insufficiency of medial circumflex femoral artery

122
Q

primary bone tumor:

soap bubble appearance on xray

A

giant cell tumor

123
Q

primary bone tumor:

onion skin appearance in bone

A

Ewing sarcoma

124
Q

conditions presenting with overproduction of uric acid

A

Lesch-Nyhan syndrome
Tumor lysis syndrome
von Gierke disease

125
Q

conditions strongly assoc with HLA-B27

A

PAIR

Psoriatic arthritis
Ankylosing spondylitis
IBD
Reactive arthritis

126
Q

Dactylitis

pencil-in-cup deformity on xray

A

psoriatic arthritis

127
Q

serum marker sensitive for drug-induced lupus

A

antihistone antibodies

128
Q 
enlarged lymph node
restrictive lung disease
bilateral hilar adenopathy
increased serum ACE
Schaumann and asteroid bodies
A

Sarcoidosis

129
Q

most common cause of death in scleroderma

A

pulmonary sclerosis

130
Q

acantholysis and nikolsky sign can be seen in

A

pemphigus vulgaris

131
Q

acanthosis with parakeratotic scaling

more spinosum, less granulosum

A

psoriasis

132
Q

sudden appearance of multiple seborrheic keratoses indicating an underlying malignancy

A

Leser - Trélat sign

GI, lymphoid malignancy

133
Q

skin layer affected in:

  • SSSS
  • TEN
A
  • Stratum Granulosum

- Epidermal-dermal junction

134
Q

Infections assoc with Erythema Multiforme

A

Mycoplasma pneumoniae

HSV

135
Q

Diseases assoc with erythema nodosum

A

sarcoidosis
crohn’s disease

leprosy
TB
strep infx

histoplasmosis
coccidioidomycosis

136
Q

wickham striae seen in

A

lichen planus

137
Q

most frequent feature of lateral medullary infarct

A

vertigo

138
Q

most common location of syringomyelia (vertebral level)

A

C8-T1

139
Q

assoc with lewy bodies (a synuclein)

A

Parkinson disease

140
Q

atrophy of caudate nuclei on imaging

A

Huntington disease

141
Q

choreiform movements
aggression
depression
dementia

CAG repeats
AD

A

Huntington disease

142
Q

regions in the brain that are highly vulnerable to ischemia

A

3 Ps
Pyramidal neurons of HIPPOCAMPUS (temporal lobe)
Pyramidal neurons of cortex (layers 3, 5, 6)
Purkinje layer of cerebellum

143
Q

Early microscopic finding in liquefactive necrosis of the brain

A

Red neurons

12 hrs after infarction

144
Q

most frequent location of a berry aneurysm

A

Anterior communicating artery

145
Q

s/sx of Lesch - Nyhan syndrome

A 
HGPRT
Hyperuricemia
Gout
Pissed off (aggression)
Retardation
dysTonia
146
Q

assoc with cystic degeneration of the putamen

A

Wilson’s disease

147
Q

most common site of ICH

A

basal ganglia

148
Q

cavernous sinus thrombosis affects which cranial nerves

A

3, 4, 5-1, 5-2, 6

149
Q

clinical triad of urinary incontinence, ataxia and cognitive dysfunction

A

Normal pressure hydrocephalus

3 Ws (wet, wobbly and wacky)
-d/t disrupted corona radiata
150
Q

s/sx of multiple sclerosis

A

SIN

Scanning speech
Intention tremors
Nystagmus

(random and asymmetrical tracts)

151
Q

spinal cord lesion assoc with charcot joints and argyll robertson pupils

A

tabes dorsalis

152
Q

peak incidence of sexual abuse

A

9 - 12 years old

153
Q

most common form of child maltreatment

A

child neglect

154
Q

most common subtype of depression

A

atypical depression

155
Q

postpartum blues usually resolve within

A

10 days

156
Q

dorsal hand calluses from induced vomiting

A

Russell sign of bulimia nervosa

157
Q

caused by decreased orexin production in the lateral hypothalamus

A

narcolepsy

158
Q

sensitive indicator of alcohol use

A

serum gamma glutamyl transferase

159
Q

intoxication with this hallucinogen leads to perceptual distortions, depersonalization and possible flashbacks

A

LSD

160
Q

most common lethal genetic disease in caucasian population

A

cystic fibrosis

161
Q

peak of delirium tremens

A

2 to 5 days after last alcohol drink

162
Q

tx of acute intermittent porphyria

A

glucose, heme

to inhibit ALA synthase

163
Q

conditions characterized by wide splitting of S2

A

RBBB
Pulmonic stenosis
(delayed RV emptying)

164
Q

conditions characterized by paradoxical splitting of S2

A

LBBB
Aortic stenosis
(delayed LV emptying)

165
Q

most frequent valvular lesion

A

mitral valve prolapse

166
Q

most common cause of coronary sinus dilatation

A

Pulmonary arterial hypertension (due to increased R-sided pressure)

167
Q

most common cause of death during acute phase of rheumatic fever

A

myocarditis

168
Q

complications of aortic stenosis

A

syncope and angina during exercise
microangiopathic hemolytic anemia
concentric LVH

169
Q

endocarditis with Strep bovis, check for underlying..?

A

colorectal carcinoma

170
Q

endocarditis with negative blood cultures

A

HACEK

Hemophilus
Actinobacillus
Cardiobacterium
Eikenella
Kingella
171
Q

Rhabdomyoma of the heart is assoc with

A

tuberous sclerosis

172
Q

most common primary cardiac tumor in adults

A

myxoma

173
Q

causes of dilated cardiomyopathy

A

ABCCCD

Alcohol abuse
Beri beri
Cocaine (chronic)
Chagas
Coxsackie B
Doxorubicin
174
Q

most common childhood systemic vasculitis

A

HSP

175
Q

small vessel vasculitis that are p-ANCA +

A

Microscopic polyangiitis

Churg Strauss

176
Q

HAMARTOMAS of tuberous sclerosis

A 
Hamartomas (CNS, skin)
Angiofibromas
Mitral regurg
Ash-leaf spots
Rhabdomyoma (cardiac)
Tuberous sclerosis
dOminant autosomal
Mental retardation
Angiomyolipoma (renal)
Shagreen patches, seizures
177
Q

congenital dse assoc with devt of berry aneurysms

A

Ehlers Danlos (type IV affecting type 3 collagen)

178
Q

dses assoc with ADPKD

A

hepatic cysts
berry aneurysms
MVP

179
Q

pathognomonic dermatologic feature of lightning strike

A

Lichtenberg figures

180
Q

most common cause of mitral stenosis

A

prior rheumatic carditis

181
Q

most common genetic cause of homocystinemia

A

MTHFR deficiency

182
Q

ESRD on dialysis is at increased risk for which malignancy

A

renal cell carcinoma

183
Q

most common cause of ARF (intrarenal azotemia)

A

acute tubular necrosis

184
Q

nephrotic syndrome can present with hypercoagulable state due to loss of

A

antithrombin III

185
Q

minimal change disease may be assoc with

A

Hodgkin lymphoma

186
Q

most common nephrotic syndrome in SLE

A

membranous nephropathy

187
Q

difference of Churg Strauss from microscopic polyangiitis

A

chAGE strauss

Asthma
Granulomatous inflam
Eosinophilia

188
Q

most common nephropathy worldwide

A

IgA nephropathy

Berger disease

189
Q

WBC casts may be seen in

A

acute pyelonephritis

190
Q

waxy casts may be seen in

A

chronic pyelonephritis

191
Q

thyroidization of kidney occurs in

A

chronic pyelonephritis

192
Q

most common type of nephrolithiasis

A

calcium oxalate stones

193
Q

most common cause of bilateral fetal hydronephrosis in boys

A

posterior urethral valves

194
Q

tuberous sclerosis is assoc with increased frequency of

A

angiomyolipoma

195
Q

PAraneoplastic syndromes assoc with REnal cell ca

A

PA RE

PTHrp
ACTH
Renin
EPO

196
Q

most common malignant renal tumor in children

A

Wilm tumor

197
Q

syndromes assoc with Wilm’s tumor

A

WAGR

Beckwith - Wiedemann

198
Q

benign counterpart of renal cell carcinoma

A

renal oncocytoma

199
Q

conditions assoc with fibrinoid necrosis

A

PAN
malignant HTN
hyperacute transplant rejection

200
Q

Goodpasture syndrome is assoc with what type of nephropathy

A

RPGN

201
Q

GBM splitting can be seen in (2)

A 
MPGN (tram-track)
Alport syndrome (lamellated GBM)
202
Q

Type I MPGN is assoc with

A

Hep B and C

203
Q

2 associations of nasal polyps

A

cystic fibrosis

aspirin-intolerant asthma

204
Q

eosinophil-derived crystals in sputum of asthma patients

A

Charcot-Leyden crystals

205
Q

spiral-shaped mucus plugs seen in asthma

A

Curschmann spirals

206
Q

interstitial lung disease
increased serum ACE
asteroid bodies

A

sarcoidosis

207
Q

only pneumoconioses with increased risk for TB

A

silicosis

208
Q

RA + coal workers’ pneumoconiosis

A

caplan syndrome

209
Q

psammoma bodies can be seen in this type of lung malignancy

A

mesothelioma

210
Q

preductal CoA
bicuspid aortic valve
horse shoe kidney

assoc with?

A

Turner syndrome

211
Q

paraneoplastic syndromes assoc with renal cell carcinoma

A

PTHrP
ACTH
ectopic EPO

212
Q

most common sources of metastatic tumors to the brain (3)

A

breast
lung
kidney

213
Q

most common location of metastatic tumors in the brain

A

gray-white junction

214
Q

most common cause of sporadic enceph in the US

A

tempor lobe encephalitis

215
Q

s/sx of cholinesterase inhibitor poisoning / organophosphate poisoning

A

DUMBBELSS

Diarrhea
Urination
Meiosis
Bradycardia
Bronchospasm
Excitation of CNS and skeletal muscle
Lacrimation
Sweating
Salivation
216
Q

permanent tissues (3)

A

skeletal muscle
cardiac muscle
nerve

217
Q

substances that attract and activate neutrophils (4)

A

LTB4
C5a
IL-8
bacterial products

218
Q 
bone marrow/liver transplant
maculopapular rash
diarrhea
jaundice
hepatomegaly
A

GVHD

219
Q

malignancies with propensity for bone mets

A

“PB KTL” lead kettle

Prostate
Breast
Kidney
Thyroid
Lung
220
Q

most common cause of death in adults with sickle cell disease

A

acute chest syndrome

221
Q

perivascular pseudorosettes are characteristic finding on biopsy

A

ependymoma

222
Q

rosenthal fibers
GFAP +
cystic lesion with mural nodule

A

pilocytic astrocytoma

223
Q

most common vitamin deficiency in the US

A

folic acid

B9

224
Q

types of susceptible infection with decreased immunoglobulins (3)

A

bacteria
enterovirus
giardia

225
Q

hypersensitivity type in Sjogren

A

type IV

226
Q

sjogren syndrome increases the risk of

unilateral enlargement of parotid gland

A

B cell / marginal zone lymphoma

227
Q

target protein of antibodies in Sjogren

A

ribonucleoproteins

228
Q

target protein of antibodies in scleroderma

A

DNA topoisomerase I

229
Q

autoimmune disease with antibodies against U1 ribonucleoprotein

A

MCTD

230
Q

complication of nephrotic syndrome char by sudden onset flank pain, hematuria and varicocele

A

renal vein thrombosis

231
Q

primary organ of osteoblastic bone mets

A

small cell lung CA
Hodgkin lymphoma
prostate CA

USMLE 2019 (10 decks)

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