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V - KCU - HDM (T2) - OMS1 > Effector Mechanisims Of T Cell Mediated Immunity (Ch. 6) > Flashcards

Effector Mechanisims Of T Cell Mediated Immunity (Ch. 6) Flashcards

1
Q

Th1 cells activate a what response

A

Cell mediated

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2
Q

Th2 cells activate what type of response

A

Ab-mediated

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3
Q

Th 17 cells activate what type of response

A

Inflammatory and anti-bacterial

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4
Q

What is the role of Th1

A

Promoting tumor immunity

Destroying intracellular pathogens

Driving autoimmunity

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5
Q

What is the role of Th2

A

Destroying parasites

Allergies

Asthma

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6
Q

What is the role of Th17

A

Controversial tumor immunity

Breaking immune tolerance

destroying Extracellular bacteria

Autoimmunity

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7
Q

Define how T-Cell cytokines usually work on effector cells

A

Either autocrine - on the same cell that produced the cytokine

Or

On nearby cells - paracrine

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8
Q

What is the action of IL-2

A

T-cell proliferation

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9
Q

What is the action of IFN - y

A

Activation of macrophages

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10
Q

What is the action of IL-4

A

B cell switching to IgE

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11
Q

What is the action of IL-5

A

Activation of Eos

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12
Q

What is the action of IL-17

A

Stimulation of acute inflammation

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13
Q

What is the action of IL-22

A

Maintenance of epithelial barriers

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14
Q

What is the role of TGF-B

A

Inhibition of T Cell activation

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15
Q

What is the role of IL-13

A

Stimulates mucus secretion and peristalsis and expulsion of parasites

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16
Q

What is the common marker for all T Cells

A

CD3

17
Q

What is the second signal to encourage proliferation fo CD8 into CTL

A

CD28 - CD80

18
Q

Define cross presentation

A
  1. Cells infected with intracellular microbes are ingested by DC’s
  2. Extracellular Ags are processed and presented as MHC II, AND MHC I
    2a. This is due to come Ag being leaked out into cytosol of DC
  3. DC presents Ag via MHC I/II and thus activates CTL as well as CD4
19
Q

Perforins are homologous with what

A

C9 compliment protein

20
Q

Granzyme B activates what in the cell

A

Caspase-3

21
Q

How do mycobacteria evade the immune system

A

Inhibition of phagolysosome fusion

22
Q

How does HSV evade the immune system

A

Inhibition of Ag presentation; HSV interferes with TAP transporter

23
Q

How does CMV inhibit Immune system response

A

Inhibition of protease activity and removal of class I MHC from ER

24
Q

How does EBV interfere with immune system

A

Inhibition of protease activity

V - KCU - HDM (T2) - OMS1 (7 decks)

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