T-Cell Mediated Immunity (Ch. 5)

Question 1

Naive T-cells recognize AG in the ________ and this initiates proliferation of T-cells to CD4 or CD8

Answer 1

LN

Question 2

T-cells react with APC and then produce what which starts differentiation into effector T-Cells

Answer 2

IL-2(autocrine)

Question 3

Memory leukocytes respond how to Ag

Answer 3

Rapidly

Question 4

What do adhesion molecules do

Answer 4

Strengthen binding of T-Cell to APC

Question 5

What do costimulators do

Answer 5

Increase responsiveness to APC

Question 6

What is signal 1

Answer 6

Ag. Recog. Via MCH:TCR

Question 7

What is signal 2

Answer 7

Costimulation via B7:CD28

Question 8

What are the components fo CD3

Answer 8

ITAMS and DE/GE

Question 9

What is CD4/CD8 responsible for in T-cells activation

Answer 9

Signal transduction

Question 10

What is CD 28 responsible for and what does it bind to

Answer 10

Costimulation

Binds to B7 (CD80/86)

Question 11

What is the role of CTLA-4 and what does it bind to

Answer 11

Inhibition

Binds to B7

Question 12

What is the role of PD-1 and what does it bind to

Answer 12

Inhibition

Binds to PD-L1

Question 13

What is the role of LFA-1 and what does it bind to

Answer 13

Adhesion

binds to ICAM - 1

Question 14

Full activation of T-Cells requires what

Answer 14

Costimulation via CD28:B7

Question 15

What is CD 69

Answer 15

T-cell marker for cell migration

Question 16

B7-1 (CD80) or B7-2 (CD86):CD28 =

Answer 16

Activation of naive T cells

Question 17

B7-1 (CD80) or B7-2 (CD86):CTLA-4 =

Answer 17

Inhibition of reg. T-cells

Question 18

ICOS-L:ICOS =

Answer 18

Activation of FThC

Question 19

PD-L1 and PD-L2:PD-1R =

Answer 19

Inhibition

Question 20

What does CD40:CD40L do

Answer 20

Increases prod of IL-12 which causes an increase of IL-2 and helps stimulate T-Cell proliferation

Question 21

What brings LCK to the ITAM to begin pathways within T-Cells

Answer 21

CD4/CD8

Question 22

What is Zap-70 and what does it do

Answer 22

Tyrosine kinase, phosphorylates PCLy1 and begins the pathway

Is located at docking sites on ITAMS

Question 23

What does calcineurin do

Answer 23

Removes phosphate from cytoplasmic NFAT, enabling it to move to nuc.

Question 24

What does Cyclosporible do

Answer 24

Inhibits calcineurin phosphatase activity and supresses NFAT

Question 25

Where is NFKB originally and what is it bound to

Answer 25

In the cytoplasm, bound to IKB before it is cleaved and activated

Question 26

What receptors for IL-2 do naive T-cells have

Answer 26

IL-2RByc (low affinity)

Question 27

After co-stimulation by B7:CD28, T-cells make what and express what receptor

Answer 27

Make IL-2 (autocrine) and express IL-2RaByc

Question 28

IL-2Ra is also called what?

Answer 28

CD25