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GIT > Peptic Ulcer Drugs > Flashcards

Peptic Ulcer Drugs Flashcards

1
Q

Triple therapy

A

Omeprexole
Metronidazole/amoxicillin
Clarythromycin

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2
Q

Duration of triple therapy

A

10-14days

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3
Q

Quadruple therapy

A

Bismuth subsalicyclate
Metronidazole
Tetracycline
PPI (omeprexole)

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4
Q

H2 blockers

A

Ronitidine
Famotidine
Cimetidine
Nizatidine

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5
Q

Stress ulcers emergency

A

H2 blockers IV

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6
Q

Adverse effect of Cimetidine

A

Inhibites p450 enzymes
Crosses placenta
Antiandrogenic (gynacomastia)

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7
Q

Most potent H2 blocker

A

Famotidine

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8
Q

H2 blocker to be eliminated by kidney

A

Nizatidine

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9
Q

Adverse effects of H2 blockers

A

Headache
Myalgia
Dizziness
Iv administration causes hallucinations and confusion

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10
Q

Proton pump inhibitors

A

Omeprezole
Iansoprezole
Rabeprezole
Esomeprezole

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11
Q

Site of action of PPI

A

Parietal cell canalicuili

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12
Q

Zollinger ellison syndrome

A

PPI

Dicyclomine

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13
Q

Duodenal ulcers

A

PPI

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14
Q

Nsaid ulcer

A

ppi

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15
Q

Esophigitis

A

PPI

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16
Q

When is PPI taken

A

30mins before largest meal

17
Q

Adverse effects of PPI

A 
Hydrochloridia
Hypergastrinemia (carcinoid tumors)
B12 def.
Colitis
diarrhea
Hypocalcemia
18
Q

Prostaglandins

A

Misoprostol (PGE1)

19
Q

Prophylactic therapy in NSAID users

A

Misoprostol

20
Q

Contraindicated in pregnancy due to contractions

A

Misoprostol

21
Q

AE of misoprostol

A

Diarrhea nausea

22
Q

Antimuscuranics

A

Diacyclomine

23
Q

AE of Diacyclomine

A

Dry mouth
Arrythmia
Constipation

24
Q

Antacids

A

Weak bases

Salts of alimunium and magnesium

25
Q

Sodium bicarbonate

A

Metabolic alkalosis

26
Q

Last line therapy for duodenal ulcers

A

Antacids

27
Q

Aluminium salts

A

Constipation

28
Q

Magnesium salts

A

Diarrhea

29
Q

Contraindications of sodium salts

A

HT
HF
RF

30
Q

Mucosal protective agents

A

Sucralfate

Bismuth subsalicyclate

31
Q

Sucralfate

A

Aluminium hydroxide+ sulfated sucrose

32
Q

Sucralfate

A

Aluminium hydroxide+ sulfated sucrose

33
Q

MOA of sucralfate

A

Binds to +vely charged proteins and forms a complex gel with epithelial cells that acts as a barrier against HCl
Increases PG and HCO3

34
Q

Why is sucralfacte not given with antacids and H2blockers

A

It requires low ph

35
Q

Bismuth subsalicyclate MOA

A

Inhibits pepsin and increases mucus

Interacts with glycoprtein in necrotic tissue to preserve ulcer

36
Q

PPIs given IV

A

Esomeprazole, lansoprazole and pantoprezole

GIT (16 decks)

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