Lecture 8

Question 1

The Hill Equation

Answer 1

Response=max.[Xa]^n/[Xa]^n + [EC50]^n

Question 2

The slope factor

Answer 2

n in Hill equation

Related to how many molecules of agonist need to bind to a receptor in order to activate it

Question 3

Potency depends on

Answer 3

Affinity
Efficacy
Receptor reserve

Question 4

Low EC50…

Answer 4

Indicates a high potnecy

because a low conc. is required to elicit a response

Question 5

Different agonists with different efficacies

Answer 5

Have different maximum responses

But still the same EC50 value

Question 6

Partial agonist

Answer 6

Cannot produce the maximal response

Question 7

Efficacy

Answer 7

The measure of a single agonist-receptor complexes ability to generate a response
Uses scale 1-0

Question 8

Maximum response for a partial agonist

Answer 8

Can only be achieved with full occupation of receptors

Question 9

In full agonists, EC50…

Answer 9

Does not = KD

Question 10

Specificity

Answer 10

Interact with a structurally defined site/receptor

Chemical properties. molecular structure

Question 11

Efficacy and drugs

Answer 11

major role in defining drug

Expression level of receptors will affect where the conc. response curve lies