Lecture 12/ 13 Flashcards
Anti-inflammatories
Acetylsalicylic acid
ASA, Derivative of salicylic acid by adding ester, better tolerated
NSAIDs action
Inhibit production of certain inflammatory mediators
Decrease prostaglandins and thromboxane production
PGI2
Vasodilator, hyperalgesia, stops platelet aggregation
TXA2
thrombotic, vasoconstrictor
PGF2X
Bronchoconstrictor, myometrial contraction
PGD2
Inhibits platelet aggregation, vasodilation
PGE2
Vasodilator, hyperalgesic
LTC4, LTD4 and LTE4
Bronchoconstrictors, increase vascular permeability
PAF
Vasodilator, increases vascular permeability, bronchoconstrictor, chemotoxin
Cyclo-oxygenases
The second enzymes in a cascade that leads to production of many mediators called prostanoids
Phospholipase A2
enzymes that create reactive intermediates from phospholipids in the plasma membrane of all cells
Arachadonate
Substrate for all cyclo-oxygenases
Thromboxine
Prevalent in platelets, normal function is to cause/facilitate clot formation
Analgesic properties
reduces certain pains
Anti-pyretic
Lowers raised temperatures