74 - Neoplasms of the Lung

Question 1

A former smoker is defined as

Answer 1

smoked ≥100 cigarettes per life- time, quit ≥1 year

Question 2

A never smoker is defined as

Answer 2

smoked <100 cigarettes per lifetime

Question 3

How many percent of new lung cancer occurs in former smokers and never smokers?

Answer 3

60%

Question 4

Incidence of lung cancer in men who have never smoked

Answer 4

1 in 12

Question 5

Incidence of lung cancer in women who have never smoked

Answer 5

1 in 5

Question 6

Lifetime probability of Lung Cancer among males

Answer 6

8%

Question 7

Lifetime probability of Lung Cancer among females

Answer 7

6%

Question 8

Risk of cigarettes smokers of developing lung cancer

Answer 8

10x

Question 9

One genetic mutation is induced for every how many cigarettes smoked?

Answer 9

15 cigarettes

Question 10

Risk of developing lung cancer among never smokers

Answer 10

9x

Question 11

Risk of developing lung cancer among those who continue to smoke

Answer 11

20x

Question 12

First degree relatives of lung cancer probands have how much risk of lung cancer

Answer 12

2-3 fold

Question 13

Loci associated with lung cancer

Answer 13

5p15
6p21
5q25

Question 14

What is the gremlin mutation involved in EGFR mutation linking to lung cancer susceptibility in never smokers

Answer 14

T790M

Question 15

Susceptibility locus on which chromosome increases risk of lung cancer among light and never smokers

Answer 15

chromosome 6q

Question 16

Reliable indicator of primary lung cancer provided a thyroid primary has been excluded

Answer 16

TTF-1

Question 17

an aspartic protease that plays an important role in maturation of surfactant B7 and is expressed in cytoplasm of type II pneumocytes

Answer 17

Napsin-A (Nap-A)

Question 18

Nap-A (+), TTF-1 (+)

Answer 18

Primary Lung Adenocarcioma

Question 19

Nap-A (-), TTF-1 (-)

Answer 19

Primary Lung Squamous Cell Carcinoma

Question 20

Nap-A (-), TTF-1 (+)

Answer 20

Primary SCLC

Question 21

CK7 (+), CK20 (-)

Answer 21

NSCLC
SCLC
Mesothelioma

Question 22

CK7(-), CK20 (-)

Answer 22

Squamous cell lung CA

Question 23

marker for NSCLC with squamous differentiation

Answer 23

p63

Question 24

Most frequently activated via gene amplification or transcriptional dysregulation in both SCLC and NSCLC

Answer 24

MYC

Question 25

Detecting cancer earlier without an effect on survival

Answer 25

lead time bias

Question 26

indolent cancers are detected on screening and may not affect survival, whereas aggressive cancers are likely to cause symptoms earlier in patients and are less likely to be detected

Answer 26

length time bias

Question 27

diagnosing cancers so slow growing that they are unlikely to cause the death of the patient

Answer 27

over diagnosis

Question 28

Most frequent s/s of lung cancer in decreasing order of frequency

Answer 28

``` cough weight loss dyspnea chest pain hemoptysis ```