Exam 2011 Flashcards
Which of the following drugs is a monoclonal antibody against vascular endothelial growth factor?
A. Imatinib (Gleevec)
B. Bevacizumab (Avastin)
B. Bevacizumab (Avastin)
Which of the following mechanisms contributes to the anticancer activity of aromatase inhibitors?
A. Inhibition of estrogen production
B. Inhibition of testosterone production
C. Increase stabilization of microtubules
D. Reduced stabilization of microtubules
A. Inhibition of estrogen production
Cyclosporine a (Sandimmune)
A. Inhibits NFAT Mediated transcription of specific cytokine genes
B. Causes cytotoxic destruction of T cells via the complement system
A. Inhibits NFAT Mediated transcription of specific cytokine genes
Rh(D) immune globulin (RhoGAM)
A. Blocks antigen recognition
B. Is inhibitor of the enzyme Calcineurin
A. Blocks antigen recognition
Prednisone
A. Causes cytotoxic destruction of T cells via the complement system
B. Can inhibit the nuclear import of the transcription factor NF-KB
B. Can inhibit the nuclear import of the transcription factor NF-KB
Sirolimus (Rapamune) is an effective immunosuppressant drug because it
A. Binds to the immunophilin FKBP12
B. Inhibits nuclear import of the transcription factor NFAT
A. Binds to the immunophilin FKBP12
Based on the FDA’s drug and pregnancy rating scale which of the following drugs is an example of a category drug
A. Acetaminophen
B. Thalidomide (Thalomid)
C. Metformin
D. Diphenhydramine (Benadryl)
B. Thalidomide (Thalomid)
What was used historically as an important alternative treatment from MRSA?
Vancomycin
What is a semi synthetic extended spectrum beta-lactam antibiotic of the penicillin family?
A. Amoxicillin/clavulante (Augmentin)
B. Ceftriaxone (Rhocephine)
C. Penicillin G
A. Amoxicillin/clavulante (Augmentin)
What is used most commonly as a prophylactic against opportunistic bacterial infection following surgery
A. Amoxicillin/clavulante (Augmentin)
B. Ceftriaxone (Rhocephine)
C. Penicillin G
B. Ceftriaxone (Rhocephine)
What is a safe, broad-spectrum antibiotic that binds the 50s ribosomal subunit to inhibit bacterial protein synthesis?
A. Minocycline
B. Daptomycin
C. Bacitracin
D. Zithromax
D. Zithromax
A drug of choice for infections due to intracellular bacteria such as chlamydia
A. Minocycline
B. Daptomycin
C. Bacitracin
D. Zithromax
A. Minocycline
A fluoroquinolone that blocks bacterial DNA gyrase
A. Sulfisoxazole (Gantrisin)
B. Ciprofloxacin (Cipro)
C. Bactrim
D. None of the above
B. Ciprofloxacin (Cipro)
A combined drug with trimethoprim and sulfamethizole
A. Sulfisoxazole (Gantrisin)
B. Ciprofloxacin (Cipro)
C. Bactrim
D. None of the above
C. Bactrim
Sulfonamides are bacterial folate synthesis inhibitors. True or false?
True
