Public Health Flashcards

1
Q

What are the aims of immunisation

A

To control communicable diseases
Prevent the onset of disease through primary prevention
Interrupt transmission of disease
Alter disease progression or limit consequences through secondary prevention

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2
Q

How are vaccines used in primary prevention

A

Given pre-exposure to antigen to develop immunity
Helps those who are currently healthy to reduce their risk of a specific disease
E.g. childhood schedule, given to older people, travel vaccines, high risk groups, occupational

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3
Q

How do vaccines work

A

They teach the immune system to recognise bacteria and viruses before the person encounters them naturally
This allows the body to effectively fight the pathogens

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4
Q

What is active immunity

A

The person has been exposed to the pathogen in the environment or artificially and produced an immune response

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5
Q

What are antigens

A

Parts of bacteria and viruses, which are recognised by the immune system
Usually proteins or polysaccharides

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6
Q

What are antibodies

A

Proteins which bind to antigens - very specific

When they bind it alerts other immune cells

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7
Q

Describe B cells

A

Mature in bone marrow

Triggered to produce antibodies when they encounter a foreign antigen

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8
Q

Describe T cells

A

Mature in thymus
Exist as CD4 and CD8
Orchestrate response of immune system by binding to other cells and sending out signals

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9
Q

What is passive immunity

A

Transfer of pre-formed antibodies from one person to another

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10
Q

How can passive immunity occur

A

Mother to unborn baby via placenta - lasts up to 1 year

From another person or animal - blood donors, human Ig or specific Ig

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11
Q

What are the advantages of passive immunity via immunoglobulin transfers

A

Rapid action
Can be given post exposure
Can control outbreaks
Used if vaccine is contraindicated

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12
Q

What are the disadvantages of passive immunity via immunoglobulin transfers

A
Short term protection 
Short time window 
Blood derived 
May trigger hypersensitivity reaction 
expensive
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13
Q

What is the preferred means of immunisation

A

Active immunity through vaccination

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14
Q

List the different types of vaccines

A
Live virus - attenuated so less effective at causing disease but still triggers immune response
Inactivated: 
Killed organism 
Subunit vaccines 
Conjugate
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15
Q

What are the benefits of inactivated vaccines

A

Safer

Suited to bacterial pathogens

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16
Q

List contraindications to vaccines

A

Confrimed anaphylaxis in response to previous dose
Cannot give live vaccines to immunosuppressed or pregnant patients
Egg allergy - used in production of some vaccines
Severe latex allergy
Acute illness (until resolves)

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17
Q

What is herd immunity

A

Protect unvaccinated individuals, through having sufficiently large proportion of population vaccinated
Those who are vaccinated stop transmission

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18
Q

Which diseases are routinely vaccinated against in the UK

A
Diphtheria 
Whooping cough 
Tetanus 
Polio 
Hib 
Meningococcal 
Measles 
Mumps 
Rubella 
Flu 
Pneumococcal 
HPV 
Hep B
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19
Q

What are notifiable diseases

A

When there is clinical suspicion or a health risk state associated with this specific disease and the doctors have a legal duty to report it to the health board

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20
Q

How do you notify a health board of a disease

A

In writing within 3 days

Notify ASAP via phone if deemed urgent

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21
Q

What is diphtheria

A

URTI characterized by sore throat, low grade fever
Get a white membrane of tonsils, pharynx etc
Caused by gram + bacterium

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22
Q

For which meningococcal disease serogroups is a vaccine available

A
A 
C
W
Y135 
B
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23
Q

How are meningococcal diseases spread

A

Spread by person-to-person contact through respiratory droplets of infected people (close contact)
In some people it is part of normal flora

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24
Q

How do the boards decide which vaccines are needed

A

Is there a need for it (epidemiological factors)?
Does it work?
Costs
Acceptability - any safety issues

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25
Q

What is the under 5 mortality rate

A

Probability of a child born in a specific year or period dying before reaching the age of 5
(per 1000 live births)

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26
Q

What is the infant mortality rate

A

Probability of a child born in a specific year or period dying before reaching the age of 1
(per 1000 live births)

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27
Q

What are the top 5 causes of under 5 mortality globally

A
Preterm birth complications 
Pneumonia 
Intrapartum-related complications - obstructed labour/asphyxia 
Diarrhoea 
Neonatal sepsis
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28
Q

What are the top 5 causes of under 5 mortality in Africa

A
Diarrhoea 
Pneumonia
Malaria
Preterm birth complications
Intrapartum-related complications
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29
Q

what percentage of child deaths are linked to malnutrition

A

45%

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30
Q

What is considered the most dangerous period of a child’s life

A

The first 24 hours

Many babies die in this window

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31
Q

What simple measures can be used to decrease neonatal death

A

Proper antenatal care: tetanus vaccine and treatment of maternal infection (HIV, syphilis)
Steroids for pre-term labour
Skilled birth attendant
Clean delivery, warm baby and able to resuscitate

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32
Q

How do you prevent neonates dying of syphilis that they got from mum

A

Give a single dose of penicillin to mum when she is pregnant

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33
Q

Why do you give steroid in pre-term births

A

Helps the lungs develop sufficiently

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34
Q

What are the risk factors for developing pneumonia in kids

A

Malnutrition
Over-crowding
Indoor air pollution
Parental smoking

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35
Q

How can you prevent pneumonia in kids

A

Vaccinations
Breastfeeding then complimentary nutrition
Good hygiene

36
Q

How do you prevent diarrhoea in kids

A

Safe drinking water, good hygiene and sanitation
Breastfeeding and good nutrition
Vaccination - rotavirus

37
Q

What is the major cause of diarrhoea in kids

A

Contaminated water and food sources

38
Q

How do you treat diarrhoea in kids

A

Oral rehydration solution (ORS)

Zinc supplements

39
Q

How do the majority of children get HIV

A

Mother to child transmission

Can occur in pregnancy, during birth or through breastfeeding

40
Q

How do you prevent kids getting HIV

A

Maternal lifelong antiretroviral treatment
Screen for and treat other STDs, especially herpes
Infant prophylaxis for 6 weeks

41
Q

How does HIV present in kids

A
Recurrent or severe childhood illnesses or oral candidiasis 
Failure to thrive or grow 
Fever 
Lymphadenopathy 
Hepatosplenomegaly  
PJP, Kaposi sarcoma, TB
42
Q

How do you treat HIV in kids

A

Highly active antiretroviral therapy (HAART)

2 NRTI’s and NNRTI or protease inhibitor

43
Q

What are the risk factors for kids developing TB

A

HIV
Malnutrition
Household contact

44
Q

How does TB present in kids

A

Chronic cough or fever lasting more than 2 weeks
Night sweats
weight loss
Lymphadenopathy

45
Q

How can you prevent TB

A

BCG vaccine

pre and post exposure isoniazid

46
Q

What causes malaria

A

Plasmodium parasite from female anopheles mosquito

Different parasites cause different severities

47
Q

How does malaria present

A

Fever
Pallor
Non-specific malaise
Very variable

48
Q

How do you treat malaria

A

Artemisinin-based combination therapy (ACT) for 3 days

Severe malaria treat with IM or IV artesunate until can tolerate oral

49
Q

How do you prevent malaria

A

Long-lasting insecticidal nets (LLINs)

Pilot projects for malaria vaccine

50
Q

What causes malnutrition

A

Lack of access
Poor feeding practices
Infection

51
Q

What is kwashiorkor

A

oedema and rounded belly due to lack of protein in the diet

Sign of malnutrition

52
Q

What is marasmus

A

Extreme skinniness seen in malnourished children

53
Q

How do you treat malnutrition

A
Need to be careful not to overload 
Treat first for hypoglycaemia, hypothermia and dehydration 
Balance electrolytes 
Treat any underlying infection 
Give micronutrients 
Initiate feeding and catch-up feeding 
Sensory stimulation
54
Q

What is the definition of health inequalities

A

Differences in health status or in
the distribution of health determinants between
different population groups
Often those in more deprived groups have poorer health

55
Q

What factors determine health inequalities

A

Unmodifiable: age, sex and genetics

Modifiable - living and working conditions, water and sanitation, access to services, education, food access

56
Q

What are the most common causes of death in young men in the UK

A
Suicide 
Drugs and alcohol 
Accidents 
Violence 
More common in deprived areas
57
Q

List some fundamental causes of health inequality

A
Global economic forces 
Political priority 
Social values 
Unequal distribution of wealth and power 
Poverty and discrimination 
NEEDS TO BE UNDONE
58
Q

List some environmental influences on health inequality

A

Economy and work
Learning
Services
Needs to prevent inequality in these areas

59
Q

What are the potential outcomes of adverse childhood experiences

A

Impairment of social, emotional and cognitive skills
Adoption of risky behaviour
Lower life expectancy

60
Q

List examples of adverse childhood experience

A

Abuse - physical, sexual & emotional
Neglect - physical and emotional
Mental illness, substance abuse and violence in the house
Incarcerated relative Divorce

61
Q

What are indicators of risk for inequalities in childhood and poor health

A
Family breakdown 
Lack of family rituals
Poor domestic and financial management 
Neglect 
Lack of discipline and routine 
Violence and abuse
62
Q

What are the symptoms of deprivation/adverse childhood experience

A
Anti-social behaviour
Isolated / withdrawn
Behavioural issues
Emotional issues
Child assuming role of carer
63
Q

What is the definition of obesity

A

Abnormal or excessive fat accumulation that may impair health - WHO
Result of long term positive energy imbalance

64
Q

What is the adult BMI range for overweight

A

25-30

65
Q

What is the adult BMI range for obese

A

> 30

66
Q

Can you use normal fixed BMI measurements for children

A

NO
Healthy BMI changes with age
Growth spurts mean height change is not always matched with proportionate weight gain

67
Q

How do you plot BMI in children (over 2 y/o)

A

Plot the BMI against age on the centile chart

Need to use the one appropriate for gender

68
Q

What are the clinical thresholds for overweight and obesity in children

A

> or equal to 91st centile is overweight

> or equal to 98th centile is obese (clinically)

69
Q

How do you plot BMI in an under 2 y/o

A

use BMI conversion chart to provide an approximate BMI centile
Usually measure length rather than height in this age group

70
Q

Can waist circumference be used in children to diagnose obesity or health risk

A

NO

71
Q

Children from deprived areas have a higher prevalence of obesity - true or false

A

TRUE

72
Q

List risk factors for obesity by the age of 3

A
Parental overweight
Black ethnicity
Greater birthweight
Smoking during pregnancy
Lone motherhood
Pre-pregnancy overweight
Maternal employment ≥21 hrs/week
Solid foods before 4 months
73
Q

Is breastfeeding protective against obesity

A

YES

If breastfed for at least 4 months

74
Q

What genetic conditions can cause obesity in childhood

A

Prader-Willi Syndrome

Bardet-Biedl Syndrome

75
Q

Describe the symptoms of Prader-Willi syndrome

A

At birth they are floppy, have weak or absent sucking
Childhood: always hungry and looking for food (hyperphagia), reduced energy requirement - prone to obesity
Low muscle tone, learning difficulty, hypogonadism and short stature

76
Q

Describe the symptoms of Bardet-Biedl Syndrome

A

Hyperphagia - always hungry
Low activity
Make them prone to obesity
Also have visual impairments, renal abnormalities, polydactyly, learning difficulties and hypogonadism

77
Q

What are the negative consequences of being overweight or obese in childhood

A

Poorer health in childhood and adulthood
Low self-esteem
Higher risk of bullying
Poorer school attendance and achievement
Poorer employment prospects

78
Q

How would you assess an obese child

A
BMI - plot on chart 
Eating habits and activity 
Social and school 
Emotional issues 
Family support 
Family history
79
Q

List common comorbidities of childhood obesity

A
Metabolic syndrome
Respiratory problems
Hip and knee problems
Diabetes
CHD
Sleep apnoea
Hypertension
80
Q

At what point would you refer an obese child for paediatric review

A

If their is serious comorbidity that requires urgent weight loss - intercranial hypertension, sleep apnoea etc
Suspected underlying medical cause - e.g. endocrine issue
Under 2’s who are severely obese

81
Q

How can you help control portion sizes

A

Smaller plates
Cook only what’s required
Parents serve rather than kids serve themselves
Age appropriate servings

82
Q

How much physical activity should a child get per day

A

Around 60 mins

83
Q

Does increased screen time increase risk of being overweight or obese

A

YES
More than 2 hours per day increases risk
Dose dependant

84
Q

Does increased sleep duration increase risk of obesity

A

NO

Decreases sleep duration is associated with obesity

85
Q

Can you use orlistat in children

A

Should only be given to >12 if physical or severe psychological comorbidities present
In exceptional circumstances such as life threatening comorbidities it may be considered <12

86
Q

Is surgery considered in overweight children

A

Surgery may be considered in post-pubertal adolescents with

very severe to extreme obesity and severe comorbidities