Lecture 21 Osteoarthritis Flashcards
1
Q
What does OA result in?
A
1) Increased tissue swelling
2) Change in color
3) Cartilage fibrillation
4) Cartilage erosion down to subchondrial bone.
2
Q
Proinflammatory cytokines in OA:
A
IL-1 and TNF-alpha (IL-6, IL-8, IL-11, IL-17)
Stimulates MMP and PGE2
IL-6: Promotes chondrocyte proliferation and number of inflammatory cells.
