Grover's Disease

Question 1

Epidemiology

Answer 1

more prevalent in caucasian men with significant photo damage > 40 years of age. Peaks in winter and the summer

Question 2

Triggers for Grovers Disease

Answer 2

heat, sweat, friction, UV radiation

Question 3

Pt with this condition are more likely to have Grovers Disease

Answer 3

asteatotic eczema

Question 4

Clinical features

Answer 4

pruritic or asymptomatic papules, vesicles, photodistribution on chest, back, and thighs

Question 5

Dermatopathology

Answer 5

acantholysis (loss of the dermasomes that hold keratinocytes together)

Question 6

ddx

Answer 6

darier and hailey hailey disease are seen in younger individuals and have a family hx. PF will be seen via direct immunoflorescence, Grovers would not be remarkable

Question 7

Treatment

Answer 7

control itch, avoid sweating and heat, topical corticosteroids/antipruritics, vit D analogues

Question 8

Systemic adverse effects of systemic corticosteroids

Answer 8

Growth retardation, hypothalamopituitary adrenal axis suppression, Cushings

Question 9

S/e topical steroids

Answer 9

atrophy, striae, hypopigment

Question 10

Elidel and Protopic

Answer 10

decrease pruritus by blocking Tcells and cytokines. Good for steroid sparing areas. Can have transient skin irritation

Question 11

Calcipotriene adverse effects

Answer 11

hypercalcemia, irritation, photosensitivity, allergic contact derm

Question 12

Isotretinoin patho

Answer 12

decreases inflammation and the size of the pilosebaceous duct. Isotretinoin sometimes used for persistent grovers