B8.060 Delayed Puberty

Question 1

when do gonad independent hypothalamic changes occur?

Answer 1

ages 2-12ish

Question 2

when do changes in steroid hormone sensitivity occur

Answer 2

ages 8-12ish

Question 3

difference between Turner girls and normal girls in gonadotropin secretion

Answer 3

since Turner girls don’t make estrogen, LH changes are purely influenced by gonad-independent factors
don’t get negative feedback by E, so LH increases at a much earlier age

Question 4

development of GnRH neurons

Answer 4

neurons originate in the olfactory placode which later forms olfactory epithelium
olfactory neurons project their axons to the olfactory bulb
GnRH neurons migrate along these neurons, eventually reaching the hypothalamus

Question 5

Kallmann Syndrome

Answer 5

genetic disorder; x-linked, autosomal recessive or dominant

anosmia and hypogonadism

Question 6

what accounts for the peak in height velocity between 10-13 in girls

Answer 6

increased production of gonadal steroids associated with puberty > E and T
increased secretion of GH and IGF1 as well