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Pharm Block 2 > Anti Hypertensive > Flashcards

Anti Hypertensive Flashcards

1
Q

Decrease SANS

Decrease HR, TPR, CO

A

A2 Agonists - Clonidine & Methyldopa

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2
Q

Tx: opiate, smoking & ethanol withdrawal

Mild & moderate HTN

A

Clonidine

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3
Q

Tx: mild & moderate HTN; HTN in pregnancy

A

Methyldope

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4
Q

SE: Depression, dry mouth

Sudden withdrawal = hypertensive crisis

A

Clonidine

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5
Q

SE: + Coombs test hemolytic anemia

A

Methyldopa

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6
Q

Inhibits VMAT - Deceasing NE release
Decreases SANS, HR, BP
Crosses BBB

A

Reserpine

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7
Q

SE: Depression, diarrhea, Increase gastric acid secretion

Contraindications: peptic ulcer & depression

A

Reserpine

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8
Q

Inhibits re uptake of NE by blocking NET
Decreases SANS, HR, BP
Doesn’t cross BBB

A

Guanethidine

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9
Q

SE: Orthostatic HTN, diarrhea, edema, sexual dysfucntion

Contraindications: can be inhibited by NET blockers - cocaine & TCAs

A

Guanethidine

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10
Q

Decrease TPR & vasodilate

A

Alpha Blockers

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11
Q

Blocks irreversibly A1 & A2

Tx: Secondary HTN

A

phenooxybenzamine - nonselective

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12
Q

Blocks reversibly A1 & A2

A

phentolamine - nonselective

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13
Q

Blocks A1 reversibly

A

selective - prazosin, terazosin, tamsulosin, doxazosin

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14
Q

Tx: HTN emergency by IV

A

Non selective - phenooxybenzamine & phentolamine

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15
Q

Tx: Essential HTN

A

Prazosin & Terazosin

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16
Q

Tx: BPH

A

Tamsulosin

17
Q 
ADR: 
1st dose effect
Nasal Blockade
Reflex tachycardia
retroejaculation
A

Alpha Blockers

18
Q

Drug of choice to tx - HTN emergency

A

Labetolol - Alpha & Beta Blocker

19
Q

Tx: HTN & reduces mortality in patients w/ heart failure

A

Carvedilol - Alpha & Beta Blocker

20
Q

Decrease s - CO, TPR, contractility, HR, relaxation rate, conduction velocity
Inhibits renin release

A

Beta Blockers

21
Q

Non Selective Beta Blockers

A 
Carteolol
Carvedilol
Labetolol
Nadolol
Penbutolol
Pindolol
Propanolol
Timolol
22
Q

Selective Beta Blockers

A 
Bisoprolol
Betaxolol
esmolol
Acebutolol
Metaprolol
Atenolol
Nebivolol
23
Q

Tx: HTN, Angina, MI, Arrhythmias, Heart Failure

A

Beta Blockers

24
Q 
ADR:
Impaired exercise tolerance
Hyperlipidemia
Diabetes (alter hyperglycemia & mask hypoglycemia)
asthma
heart block/heart failure
sexual dysfunction
A

Beta Blockers

25
Q

nervousness, tachycardia, angina, HTN & heart infection

A

Sudden withdrawal from Beta Blockers

26
Q

Antidote for over dose of Beta blockers causing heart block/ heart failure

A

glucagon

27
Q 
BP >/= 180/110
without end organ damage 
severe headache 
SOB
nosebleeds
sever anxiety
A

Hypertensive urgency

28
Q 
BP >/= 180/120
with damage to at least one organ (brain, heart, kidney)
stroke
heart attack
loss of kidney fucntion
loss of consciousness & memory loss
damage to eye 
aortic dissection
angina
pulmonary edema
eclampsia
A

Hypertensive emergency

29
Q

Hypertensive tx for blacks

A

Thiazide & CCB

30
Q

stage 1 HTN tx

A

mono therapy

31
Q

stage 2 HTN tx

A

combo therapy - 2 agents with different MOA

32
Q

patient has diabetes or kidney disease with HTN what id the treatment

A

ACE-I, ARBs

33
Q

blood pressure goal

A

less than 130/80 mmHg

34
Q

used to tx HTN in pregnancy

A

Labetolol
Nifedipine
methyldopa

Pharm Block 2 (22 decks)

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