Non Selective COX inhibitors

Question 1

rapidly absorbed in the stomach; anti-platelet action; irreversibly binds COX which is why it has such an affect on platelets

Answer 1

aspirin

Question 2

MOA: acetylation of COX1 and COX2 irreversibly binding them; anti platelet action due to acetylation of COX1

Answer 2

aspirin

Question 3

used in MI and TIA in low doses; also used in rheumatic fever - high dose

Answer 3

aspirin

Question 4

ADR: gastric and duodenal ulcer, hepatotoxicity, asthma

Answer 4

aspirin

Question 5

occurs when a child with a viral fever aspirin causing hepatic encephalopathy

Answer 5

Reyes syndrome

Question 6

at toxic levels - respiratory alkalosis, metabolic acidosis

Answer 6

aspirin

Question 7

treatment for aspirin toxicity

Answer 7

sodium bicarb

Question 8

vomiting, tinnitus, vertigo, reversible hearing loss

Answer 8

salicylism - from high doses of salicylates

Question 9

more potent anti inflammatory action than other NSAIDS

Answer 9

indomethacin

Question 10

used in ra, gout, ankylosing spondylitis and PDA to close

Answer 10

indomethacin

Question 11

ADR: abdomen pain, GI hemorrhage, headache

Answer 11

indomethacin

Question 12

good anti inflammatory

used in chronic or acute musculoskeletal pain; inflammatory swelling and fever, RA, gout, AS, PDA

Answer 12

Ibuprofen
diclofenac
naproxen

Question 13

used for pain control after surgery

SE: gi irritation, renal damage, cross allergy with ASA

Answer 13

ketorolac

Question 14

inhibits cox 3

better in CNS

Answer 14

Acetaminophen

Question 15

treatment for over of acetaminophen

Answer 15

N acetyl cysteine