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Fiser absite > Chapter 13 - Inflammation and Cytokines > Flashcards

Chapter 13 - Inflammation and Cytokines Flashcards

1
Q

Injury to the epithelium causes:

A

exposure of collagen, platelet-activating factor release, tissue factor release from endothelium.

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2
Q

When platelets bind to exposed collagen matrix, they release________ which leads to _________ recruitment

A

platelet derived growth factor; PMN and Macrophage

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3
Q

______ are the dominant cells in wound healing. They release_________.

A

Macrophages. PDGF, IL-1 and TNF-alpha

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4
Q

Actions of PDGF:

A
  • chemotactic and activates PMNs and Macros
  • Chemotactic and activates fibroblasts
  • Angiogenesis
  • Epithelialization
  • Chemotactic for smooth muscle
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5
Q

Actions of EGF:

A
  • chemotactic and activates fibroblasts
  • Angiogenesis
  • Epithelialization
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6
Q

Actions of FGF (Fibroblastic growth factor):

A
  • Chemotactic and activates fibroblasts
  • Angiogenesis
  • Epithelialization
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7
Q

Platelet Activating factor generated where? does what?

A

Generated by phospholipase in endothelium

-Stimulates inflammatory cells, chemotactic, increases adhesion molecules

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8
Q

These cytokines are chemotactic for inflammatory cells:

A
  • TGF beta
  • PDGF
  • IL-8
  • LTB-4
  • C5a and C3a
  • PAF
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9
Q

These cytokines are chemotactic for Fibroblasts:

A
  • TGF-beta
  • PDGF
  • EGF
  • FGF
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10
Q

These cytokines cause angiogenesis:

A
  • TGF-beta
  • EGF
  • FGF
  • TGF-alpha
  • IL-8
  • Hypoxia
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11
Q

These cytokines cause epithelialization:

A
  • TGF-beta
  • PDGF
  • EGF
  • FGF
  • TGF-alpha
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12
Q

How long do PMN’s last in tissue? in blood?

A

1-2 days in tissue, 7 days in blood

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13
Q

How long to Platelets last?

A

7-10 days

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14
Q

How are eosinophils involved in type I hypersensitivity reactions?

A
  • Have IgE receptors for allergen

- Release major basic protein- stimulates basophils and mast cells to release histamine

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15
Q

How are Basophils involved in type I hypersensitivity reactions?

A
  • Have IgE receptors

- Main source of histamine in blood

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16
Q

How are Mast cells involved in type I hypersensitivity reactions?

A

Primary cell in type I hypersensitivity reactions. Main source of histamine in tissues other than stomach.

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17
Q

What does Histamine do?

A
  • Vasodilation
  • Tissue edema
  • Postcapillary leakage
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18
Q

What does Bradykinin do?

A
  • Vasodilation
  • Increased Permeability
  • Pain
  • Contraction of Pulmonary Arterioles
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19
Q

The two main initial cytokines released in response to injury and infection are?

A

TNF alpha and IL-1

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20
Q

This cell type is the major producer of TNF

A

Macrophages

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21
Q

Cachexia is mediated by this cytokine

A

TNF

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22
Q

TNF’s main functions are?

A
  • Increases adhesion molecules
  • Procoagulant
  • Activates neutrophils and macrophages
  • Fever, hypothermia, tachycardia, ^ Icardiac output, decrease SVRI
  • (high doses cause circulatory collapse and multisystem organ failure)
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23
Q

This cell is the main source for IL-1

A

Macrophages

24
Q

IL-1 causes fever through this mechanism

A

PGE-2 Mediated increased thermal set point (NSAIDS block PGE2)

25
Q

How does fever occur in atelectasis?

A

Alveolar macrophages release IL-1

26
Q

What does IL-1 do to IL-6 production?

A

increases it.

27
Q

What does IL-6 do?

A
  • Increases Hepatic acute phase proteins (C-reactive protein, amyloid A)
  • Lymphocyte activation
28
Q

What cells release interferons?

A

Lymphocytes in response to viral infections

29
Q

What doe interferons do?

A

Activate macrophages, natural killer cells, cytotoxic T cells
-Inhibit viral replication

30
Q

What is the most important stimulator for hepatic acute phase proteins?

A

IL-6

31
Q

These proteins are increased in Hepatic Acute Phase Response:

A
  • C-reactive protein (opsonin, ^ complement)
  • Amyloid A and P
  • Fibrinogen
  • Haptoglobin
  • Ceruloplasmin
  • Alpha 1 antitrypsin
  • alpha 1 chymotrypsin
  • Complement
32
Q

These proteins are decreased in the hepatic acute phase response:

A

Albumin, transferrin

33
Q

The first step in cell adhesion:

A

Rolling; L-selectins on leukocytes bind to E and P selectins

34
Q

Second step in cell adhesion:

A

Anchoring; Beta 2 Integrans (CD11/18 molecules) in leukocytes bin ICAMs

35
Q

Where are ICAM, VCAM, PECAM, FLAM located and what do they do?

A

Endothelial cells. Bind Beta 2 Integrins. Also help with transendothelial migration

36
Q

The classic complement pathway is activated by what?

A

Antigen-Antibody Complex (IgG or IgM)

37
Q

These factors are found only in the classic pathway:

A

C1, C2, C4

38
Q

The alternative pathway is activated by what?

A

endotoxin, bacteria

39
Q

These factors are found only in the alternative pathway:

A

B, D, and P (Properdin)

40
Q

This is factor is common to both and is the convergence point:

A

C3

41
Q

This electrolyte is needed for both pathways

A

Mg

42
Q

These are the Anaphylatoxins of the complement, they do what?

A

C3a, C4a, C5a; increase vascular permeability, smooth muscle contraction, activate mast cells and basophils.

43
Q

This is the membrane attack complex of complement

A

C5b-9b

44
Q

Complement Opsonization is caused by:

A

C3b

45
Q

Complement Chemotaxis is caused by:

A

C3a and C5a

46
Q

PGI2 and PGE2 cause what?

A
  • Vasodilation,
  • bronchodilation
  • vascular permeability
  • Inhibit platelets
47
Q

PGD2 causes what?

A
  • Vasodilation
  • Bronchoconstriction
  • Increased vascular permeability
48
Q

NSAIDs do what?

A

Inhibit cyclooxygenase reversibly

49
Q

Aspirin does what?

A
  • Inhibits cyclooxygenase irreversibly

- Inhibits platelet adhesion by decreasing TXA2

50
Q

Steroids do what to eicosanoid production?

A

Inhibit phospholipase which converts phospholipids to arachidonic acid.

51
Q

What are LTC4, LTD4, LTE4?

A

Leukotrienes; slow reacting substances of anaphylaxix. Bronchoconstriction, vasoconstriction, increased permeability

52
Q

What is LTB4

A

Chemotactic leukotriene

53
Q

How long before catecholamines peak after injury?

A

24-48 hours

54
Q

Where is Norepinephrine released from?

A

Sympathetic postganglionic neurons and Adrenal Medulla

55
Q

Where is Epinephrine released from?

A

Adrenal Medulla

56
Q

What are the neuroendocrine responses to injury?

A

Afferent nerves from injury site stimulate CRF, ACTH, ADH, Growth Hormone, Epi, Nor-Epi

Fiser absite (58 decks)

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