ADRs

Question 1

Synthetic T4

Answer 1

Iatrogenic hyperthyroidism –>Tachycardia, atrial fibrillation
Warning: a-fib
DI: PPIs, Estrogens (BC), Ca, Mg, Fe, Carbamazepine, Rifampin, Sertraline, Imatinib, Amiodarone, Iodine, Coumadin, Digoxin

Question 2

Synthetic T3

Answer 2

palpitation
insomnia
nervousness
similar ADRs to synthetic T4

Question 3

Thyroid USP

Answer 3

Smells like pig

ADRS and DI same as with levothyroxine or liothyronine

Question 4

Methimazole

Answer 4

Rash
GI upset
Arthralgias
HA
Rare: agranulocytosis (low WBCs), sore throat, fever → check CBC
DI: anticoagulants, beta blockers, digoxin, theophylline

Question 5

Propylthiuracil

Answer 5

FDA warning: liver failure

Same ADRs as methimazole

Question 6

Cabergoline

Answer 6

GI at first (N,V, constipation)
HA
Dizziness

Question 7

Bromocriptine (Parlodel)

Answer 7

N,V, D
HA
lightheadedness
dizziness
nervousness
fatigue
abdominal pain
*N&D (diarrhea=biggest difference from cabergoline),

Question 8

Octreotide (sandostatin)

Answer 8

N, V, D
abdominal cramps
flatulence
fat malabsorption (usually subside in 2 wks)

Question 9

Pegvisomant (Somavert)

Answer 9

Inj site pain
N/D
flu-like symptoms

Question 10

Phenoxybenzamine

Answer 10

hypotension
tachy
miosis
nasal congestion
erectile dysfunction

Question 11

Calcium gluconate

Answer 11

tingling
heat sensation
chalky taste

Question 12

Calcitriol

Answer 12

Hypercalcemia
hypercalciuria
hyperphophatemia
Vit D intoxication