8 - Insomnia Flashcards

1
Q

How often does insomnia need to occur for the diagnosis?

A

3 nights/week for 3 months

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2
Q

Everyone should be screened for ?

A

obstructive sleep apnea

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3
Q

Non-pharms?

A

sleep hygiene specific to the patient

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4
Q

What are the 3 categories for insomnia agents?

A
  • Benzos
  • BZD receptor agonists
  • Other hypnotics
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5
Q

What are the 4 BZD approved by HC for insomnia?

Which ones are not recommended?

A
  • flurazepam, nitrazepam, temazepam and triazolam

- the first 2 are not recommended, esp in elderly (long t1/2 and can accumulate)

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6
Q

Which benzos should you try first?

A
  • temazepam

- triazolam

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7
Q

Which BZD is more suited for initial insomnia than maintenance insomnia?

A

triazolam - has fast onset and short DOA so more suited for initial insomnia than maintenance insomnia

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8
Q

Describe when patients should take oxazepam

A

Slow absorption

  • take 60-90 mins before bed if used for initial insomnia
  • take at bedtime if used for maintenance insomnia
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9
Q

What class is zopiclone from?

A

BZD receptor agonist

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10
Q

Zopiclone: patients should not drive until at least ___ hours after the dose

A

12

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11
Q

When is zolpidem used for?

A

for complex sleep disorders

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12
Q

Who should get a lower dose of Zolpidem?

A

women and elderly

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13
Q

Do not combine zolpidem with _____

A

alcohol

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14
Q

High doses of ______ may be useful in those who want to avoid BZD

A

L-tryptophan (> 1 g)

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15
Q

Should people try melatonin?

A

Yes - evidence for efficacy is controversial but bc it has low s/e everyone should try it

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16
Q

What is the TCA approved for sleep maintenance insomnia?

A

doxepin

17
Q

______ can double doxepin serum concentrations

A

cimetidine

18
Q

_____ is available in US only and has high selectivity for melatonin receptors. It is effective and well-tolerated.

A

Rameltron

19
Q

What is Suvorexant?

A
  • orexin 1 and 2 receptor antagonist
  • not available in Canada
  • next day somnolence can occur and can increase digoxin levels
20
Q

What is orexin?

A

orexin sustains wakefulness, so blocking it’s receptors promotes sleep

21
Q

What can we recommend for pregnancy after non-pharms?

A
  • although lacking evidence, zopiclone could be used intermittently (assess risk vs benefit)
  • do not use BZD - can cause orofacial malformations
22
Q

What can we recommend for breastfeeding after non-pharms?

A

BZD, zolpidem or zopiclone

*not doxepin