Week 3 haem

Question 1

abl

Answer 1

c9

Question 2

bcr

Answer 2

chromosome 22

Question 3

white pulp

Answer 3

cd4+

Question 4

what is the inherited cause of pancytopenia

Answer 4

fanconis anaemia

Question 5

acute leukaemia

Answer 5

proliferation of abn progenitors with block in differentiation/ maturation

Question 6

lymphoma symptoms

Answer 6

night sweats fatigue itch without rash pain on alcohol

Question 7

fanconis anaemia

Answer 7

defect in dna repair / ribosomes

Question 8

malignant haemopoesis

Answer 8

increased proliferation decreased differentiation decreased maturation decreased apoptosis

Question 9

clock face nucleus

Answer 9

plamsa cell

Question 10

paraprotein

Answer 10

marker of underlying b cell disorder

Question 11

what are the secondary acquired causes of pancytopenia

Answer 11

drug induced aplasia vitamin deficiency infections mets storage diseases

Question 12

treat cml

Answer 12

tyrosine kinase inhibitors

Question 13

what is the main cause of pancytopenia due to increased destruction?

Answer 13

hypersplenism

Question 14

treat polycythaemia rubra vera

Answer 14

venesect aspirin chemo

Question 15

tear drop shaped rbcs

Answer 15

myelofibrosis

Question 16

young

Answer 16

all

Question 17

eg tyrosine kinase inhibitors

Answer 17

imatinib

Question 18

auer rods

Answer 18

aml

Question 19

chronic myeloid leukaemia

Answer 19

proliferation of abn progenitors with no differentiation/ maturation block

Question 20

jak2 calcr

Answer 20

myelofibrosis

Question 21

jak2 calr mdl

Answer 21

essential thrombocythaemia

Question 22

treat essential thrombocythaemia

Answer 22

anti platelet

Question 23

elderly

Answer 23

aml

Question 24

cml

Answer 24

Philadelphia chromosome

Question 25

excess of blasts

Answer 25

acute leukaemia i

Question 26

what are the primary acquired causes of pancytopenia

Answer 26

aplastic anaemia myelodysplastic syndrome acute leukaemia

Question 27

jak2

Answer 27

polycythaemia rubra vera