liver

Question 1

what is bilirubin predominantly derived from

Answer 1

Hb breakdown in spleen

Question 2

what is bilirubin bound to when carried in the blood

Answer 2

albumin

Question 3

what is unconjugated bilirubin conjugated into, where and by what

Answer 3

conjugated in liver by glucuronyl transferase into bilirubin glucoronide

Question 4

what is unconjugated bilirubin conjugated into, where and by what

Answer 4

conjugated in liver by glucuronyl transferase into bilirubin glucoronide

Question 5

where is bilirubin glucoronide secreted into and via what

Answer 5

into duodenum in bile via bile duct

Question 6

where is bilirubin glucoronide secreted into and via what

Answer 6

into duodenum in bile via bile duct

Question 7

what is bilirubin glucoronide degraded into in the gut by bacteria

Answer 7

urobilinogen, stercobilinogen - remain water soluble

Question 8

fate of stercobilinogen

Answer 8

most oxidised to stercobilin (causes brown colour of faeces) in GIT, or reabsorbed and returned to liver via enterohepatic circulation

Question 9

fate of stercobilinogen

Answer 9

most oxidised to stercobilin (causes brown colour of faeces) in GIT, or reabsorbed and returned to liver via enterohepatic circulation

Question 10

enterohepatic circulation of bile salts

Answer 10

liver → excereted into biliary tree and GIT → absorbed in GIT → reabsorbed from portal circulation into liver from blood by active transport mechanism → very small amount lost so some primary bile salts produced in liver