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Metabolism CC > Steroids > Flashcards

Steroids Flashcards

1
Q

Corticosteroids

A

Used in treatment of inflammatory + autoimmune diseases

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2
Q

Lowest plasma circadian cortisol levels

A

1-5 ug/100ml

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3
Q

Highest plasma circadian cortisol levels

A

6-20 ug/100ml

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4
Q

Stress- induced cortisol plasma levels

A

30-100 ug/100ml

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5
Q

As Cortisol increases

A

Receptor conc increases

Mediator conc decreases

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6
Q

Side effects

A 
Peptic ulcers 
Oedema
Hypertension
Osteoporosis (increases osteoclast activity, decreases osteoblast)
Avascular necrosis
Glaucoma
Juvenile growth retardation
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7
Q

Cushing’s syndrome

A

High cortisol levels due to administration of corticosteroids

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8
Q

Lipid metabolism

A

Increased lipolysis by adipocytes

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9
Q

CNS

A

Regulation neuronal excitability

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10
Q

Skeletal system

A

Maintenance muscular tone

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11
Q

Carbohydrate metabolism

A

Inhibit insulin

Stimulate glucagon secretion

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12
Q

Immune system

A

Immunosuppressive

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13
Q

Human Glucocorticoid receptor

A

Found in cytoplasm + nucleus of most cells in body- can enter through cell membrane as are lipid
2 main forms
Alpha- binds steroid
Beta- does not bind steroid

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14
Q

Genomic (slow) activity

A

Transactivation of gene transcription by direct interaction with DNA
Transrepression by interaction with other proteins in cytoplasm or nucleus

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15
Q

Alpha receptor

A

Transactivation
Ligand binds to alpha to activate receptor
Translocated to nucleus
Regulated gene expression

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16
Q

Transrepression

A

GC binds to DNA where pro-inflammatory transcription factors would
Prevent gene expression of inflammatory transcription factors
–> reduces inflammation

17
Q

Non-genomic (fast) activity

A

Activated GR bind to proteins in cytoplasm/membranes to cause immediate effect

18
Q

Steroid drug resistance

A

Beta receptor levels high

19
Q

Synthetic forms

A

Dexamethasone
Betamethasone
Prednisone
Prednisolone

Metabolism CC (29 decks)

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