Hypothyroidism Flashcards
1
Q
Pathophysiology
A
Thyroid function falls below normal
Reduced hormone production
MBR decreases
2
Q
Aetiology of primary (4)
A
Autoimmune
Idiopathic atrophy
Neoplastic destruction of thyroid tissue
Rarely congenital
3
Q
Aetiology of secondary (2)
A
Destruction of TSH producing cells of pituitary by tumour
Rarely congenital
4
Q
Clinical signs (8)
A
Lethargy Mental dullness Weight gain Skin thickening and darkening Alopecia of flank and tail Constipation +/- Diarrhoea Chronic skin and ear infections
5
Q
Diagnosis (5)
A
Hx/cs/exam Serum total and free T4 TSH stim. - increased due to compensation Thyroid imaging Hormone supplementation response test
