Immuno3

Question 1

What do NK cells use to induce apoptosis?

Answer 1

Perforin & Granzymes

Question 2

T/F - NK cells are the only lymphocyte member of Innate immune system.

Answer 2

True

Question 3

What increases NK cell activity?

Answer 3

IL-2
IL-12
INF-ß
INF-a

Question 4

Th1 cells secrete?

Answer 4

IFN-gamma

Question 5

Th2 cells secrete?

Answer 5

IL-4
IL-5
IL-10
IL-13

Question 6

Th1 function.

Answer 6

Macrophages

Question 7

Th2 function.

Answer 7

Recruits Eosinophils for parasite defense

Promotes IgE production by B cells

Question 8

Th1 is inhibited by.

Answer 8

IL-4
IL-10
(from Th2 cell)

Question 9

Th2 is inhibited by.

Answer 9

INF-gamma

from Th1 cell

Question 10

Helper T cells have ____, which bind to ____ on APCs.

Answer 10

CD4

MHCII

Question 11

Cytotoxic T cells induce apoptosis in what cells?

Answer 11

Virus-infected
Neoplastic
Donor graft cells

Question 12

What does Cytotoxic T cells release?

Answer 12

Preformed Proteins:

• Perforin
• Granzyme
• Granulysin

Question 13

Function of Perforin.

Answer 13

Helps to deliver the content of grandules into Target Cell

Question 14

Function of Granzyme.

Answer 14

Serine Protease

Activates apoptosis inside Target Cell

Question 15

Function of Granulysin.

Answer 15

Antimicrobial

Induces Apoptosis

Question 16

Cytotoxic T cells have ___, which bind to ____ on virus-infected cells.

Answer 16

CD8

MHCI

Question 17

What is the function of Regulatory T cells?

Answer 17

Help maintain specific immune tolerance by suprressing CD4 and CD8 T-cell effector function

Question 18

What cell surface markers do Regulatory T cells express?

Answer 18

CD3
CD4
CD25 (a-chain of IL-2 receptor)