8 - Cytos Flashcards Preview

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Flashcards in 8 - Cytos Deck (18)
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1
Q

mucocitus is associated with what cytos (3)

A

methotrex
flurouricil
anthracyclines (rubicins)

2
Q

pre-disposing factors to tumour lysis syndrome (3)

features of tumour lysis syndrom (4)

A

hyperuricaemia, dehydration, renal impairment

features include :
high K, uric acis, phos and low Ca

3
Q

two drugs for tumour lysis syndrome

A

allopurinol

rasburicase

4
Q

when is the peak time for bone marrow supression

A

7-10 days after

5
Q

what type of drugs might cause male sterility

A

alkylating agents

6
Q

acute treatment for vomiting - low (2)

high (3)

A

dexamthasone and lorazepam

for higher risk - 5ht3 antag with dex
or
apreiptent

7
Q

delayed onset n and v treatment (2)

A

5ht3 antag

metoclopramide

8
Q

what type of cyto is associated with life threatening dose related cardio tox

A

anthracyclines (like -rubicins)

9
Q

folinic acid is used for

A

recovery from methotrexate induced mucositis and myelosuppression

10
Q

three drugs causing haemorragic cystitis

A

oxazaphosphorines
cyclophosphamide
ifosfamide

11
Q

preventative therapy for haemorragic cystitis

A

mesna

12
Q

name some alkylating drugs

risk of prolonged use of akylating agents (1)

A

carmustine
chroambucil
cyclophos

risk of secondary malgnancy

13
Q

what type of drug is doxorubicin

what are some risks

A

anthracycline

cardiotox (liposomal formulations may reduced but increased infusion reactions like hand and foot)

elevated billirubin

14
Q

what is dexrazoxane for?

A

anthracycline extraversation ofr prevention of toxicity (with things ending in rubicin)

15
Q

what is palifermin?

A

for the meanagement of oral mucocytis

16
Q

what is rasburincase for?

A

prevent hyperuricaemia (tumor lysis sndrome)

17
Q

when can tamoxifen be used in realation to menopause

what receptor positive must it be

A

pre and peri menoupausal

oestrogen receptor positive

18
Q

trastuzumab is for what sort of cancer

A

her2 positive