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pharma > Gout Drugs > Flashcards

Gout Drugs Flashcards

1
Q

Antigout, inhibits Microtubule assembly
For Gout and Familial Mediterranean fever
SE: Agranulocytosis, Diarrhea (signal of toxicity)

A

Colchicine

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2
Q

Used in the initial treatment of gout as replacement for colchicine

A

Indomethacin

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3
Q

Antigout, uricosuric agent
Competes with uric acid for reabsorption in the proximal tubules
AE: Nephrotic Syndrome, Nephrolithiasis
May precipitate gout in the early stages (avoid with colchicine and indomethacin)
May be given with antimicrobial agents

A

Probenecid

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4
Q 
Antigout Xanthine oxidase inhibitor
IRREVERSIBLE inhibits Xanthine Oxidase 
1st line tx for chronic gout
SE: Cataracts, Aplastic Anemia
Inhibits Mercaptopurine and Azathioprine
A

Allopurinol

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5
Q

Antigout Xanthine oxidase inhibitor
Non purine REVERSIBLE Xanthine oxidase inhibitor
Used for Allopurinol intolerance and Tumor Lysis Syndrome
SE: Liver Dysfunction
More effective than Allopurinol

A

Febuxostat

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6
Q

Urate lowering enzyme

A

Pegloticase

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7
Q

IL 1 Pathway inhibitor

A

Anakinra
Canakinumab
Rilonacept

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