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Pharm > Immunomodulating Drugs > Flashcards

Immunomodulating Drugs Flashcards

1
Q

Cyclosporine

MOA

Side Effects

A

MOA:

binds to cyclophilin, which inhibits calcineurin from transcribing IL-2

Side Effects:

gingival hyperplasia, nephrotoxicity, HLD, male-pattern hair growth in women

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2
Q

Cetuximab

MOA

Side Effects

A

MOA:

TNF-a inhibitor that combines with polyethylene glycol

Side Effects: allergic reactions

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3
Q

Rituximab

MOA

Side Effects

A

MOA:

anti CD20 monoclonal antibody that causes lysis of lymphocytes

Side Effects: B symptoms

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4
Q

Bevacizumab

MOA

Side Effects

A

MOA:

Recombinant VEGF antibody that inhibits formation of new blood vessels

Side effects:

GI bleeding and perforation, pulmonary hemorrhage

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5
Q

Anti-TNF alpha inhibitor that uses a recombinant receptor

A

Etanercept

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6
Q

Anti-TNF alpha inhibitor that has a mouse variable region

A

Infliximab

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7
Q

Anti-TNF alpha inhibitor that uses human variable regions

A

Adalimumab Golimumab

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8
Q

Trastuzumab

MOA

Side Effects

A

MOA:

Recombinant HER2 receptor that inhibits proliferation of breast cancer

Side Effects:

heart failure, pulmonary toxicity

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Pharm (10 decks)

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