ALCOHOL PHARMA

Question 1

STD ALCOHOLIC DRINK

Answer 1

0.6oz alcohol =
=12 oz beer
=5 oz wine
=1.5 oz distilled spirits (40%)
blood alcohol levels fall 20mg/dl/h
body clears 1oz/3hours

Question 2

ALCOHOL ENZYMES

Answer 2

EtOH — (ADH) —> acetaldehyde — (acetaldhyde dehydrogenase) —> acetate
broken down by alcohol dehydrogenase (ADH) and mixed function oxidases such as P45011E1 (CYP 2E1)

Question 3

METADOXINE

Answer 3

enhances metabolic clearance of alcohol

Question 4

ALCOHOL CNS DEPRESSANT

ADDITIVE EFFECTS BY

Answer 4

barbiturates
benzos
general anesthetic
volatile organic solvents
anticonvulsives
antihistamines

Question 5

ALCOHOL ENHANCES

Answer 5

acetaminophen - hepatotix

NSAIDS - GI

Question 6

MOLECULAR SITES OF ALCOHOL ACTION

Answer 6

GABA and glycine receptors
glutamate activated ion channels
5-HT3 receptors
acetylcholine nicotinic receptors
adenosine triphosphate gated ion channels
potassium and calcium selective ion channels

Question 7

ALCOHOL ACTION ON NEUROTRANSMITTERS

Answer 7

adenosine
dopamine (VTA DA neurons -> DA release in nucleus accumbent, prefrontal cortex +)
opioids and other neuropeptides
serotonin
endocannabinoids (CB1)
neuroimmune modulators

Question 8

ALCOHOL TOXICITY STATES

Answer 8

low levels (10-50mg%) dec anxiety, incr well being, socialness
mod (80-100) impaired judgement/motor function
higher (150-200) ataxia, reduced reaction, blackout
anesthetic (300-400) severe motor impairment, vomiting, loss of consciousness
lethal (400-500) and above