Hypothalamic and Pituitary Pharmacology

Question 1

Growth hormone (somatotrophin) is given to children with ______________.

Answer 1

poor growth due to Turner syndrome or Prader-Willi

Question 2

In those with acromegaly who do not want surgery, ______________ are the preferred medical treatment.

Answer 2

somatostatin analogs

Question 3

Somatostatin activates a ______________ receptor.

Answer 3

Gi/o

Question 4

In addition to antipsychotics, ___________ can also cause hyperprolactinemia.

Answer 4

estrogen

Question 5

ADH has two effects. Which one occurs at lower doses?

Answer 5

The antidiuretic effect occurs at lower doses. The vasopressor effect (on V1 receptors) occurs at higher doses.

Question 6

All V2 antagonists end with the suffix __________.

Answer 6

-vaptan

Question 7

In general, use of GH for “anti-aging” is associated with _______________.

Answer 7

minimal changes in body composition and increased risk of adverse effects; there is not much research on this, however

Question 8

Dopamine agonists are not as effective as ___________ in treating gigantism.

Answer 8

somatostatins

Question 9

ADH must be administered _______________.

Answer 9

parenterally (IV, IM, or intranasal)

Question 10

Release of _________ can be inhibited by alcohol.

Answer 10

ADH

Question 11

In someone with nephrogenic diabetes insipidus, thiazides cause ________________.

Answer 11

paradoxical antidiuresis

Question 12

Growth hormone binds to what type of receptor?

Answer 12

JAK-STAT

Question 13

You’ll need to treat someone with ________ dwarfism with IGF-1 instead of Somatropin.

Answer 13

Laron

Question 14

_____________ can cause increases in intracranial pressure.

Answer 14

Growth hormone

Question 15

_______________ decrease the release of TSH.

Answer 15

Somatostatin and T4/T3