Tuberculosis

Question 1

What is the mm of induration which indicates a positive test?

Answer 1

>5mm is positive for:
HIV PTs
Recent contact w/ TB PT
Fibrotic changes on CXR
Immunosuppresed PTs (I.e. on prednisone)
PTs with organ transplants

>10mm positive for
Recent immigrants <5yrs
IVDA
Children <4 y.o.
Residents/employees in high risk settings
Mycobacteriologic personnel

> 15mm positive for
Person without known risk factors

Question 2

What are some possible reasons for false negatives on Skin tests?

Answer 2

HIV
Steroid use
Anergy
Malnutrition

Question 3

What is the most specific and sensitive TB test?

Answer 3

Quantiferon gold

Question 4

Which drug can cause peripheral neuropathy?

Answer 4

Isoniazid (INH)

Question 5

If someone receives the BCG vaccine; it can cause positive results on which tests?

Answer 5

Skin test (PPD) Mantoux Test
BUT NOT THE QUANTIFERON GOLD

Question 6

If someone receives the BCG vaccine; it can cause positive results on which tests?

Answer 6

Skin test (PPD) Mantoux Test
BUT NOT QUANTIFERON GOLD

Question 7

What are the four first line drugs for Tb?

Answer 7

Isoniazid (INH)
Rifampin (RIF)
Ethambutol
Pyrazinamide

Drugs taken for 6 to 9 months