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Vitamin > Vitamin B12 > Flashcards

Vitamin B12 Flashcards

1
Q

Vitamin B12 is also called

A

Cobalamin

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2
Q

Vitamin B12 sources

A

Liver, Red meat, fish, eggs, dairy products, and cereals

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3
Q

Remethlation of Homocysteine to methionine requires?

A 
Vitamin B12(cobalamin)
N5-Methyltetrahdrofolate
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4
Q

Deficiency of Cobalamin causes what type of anemia?

A

Megaloblastic Anemia

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5
Q

B12 deficiency can be determined by the level of acid in the blood. Name that acid.

A

Methylmalonic acid

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6
Q

Methylmalonic acid and Propionic acid accumulate in the myelin sheath of neurons. This causes?

A

Neuropsychiatric symptoms. The CNS effects are irreversible.

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7
Q

Why is Methylmalonic acid level elevated in people with B12 deficiency?

A

The enzyme (methylmalonyl reductase) responsible for converting methylmalonyl CoA to Succinyl CoA requires B12.

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8
Q

Remethylation of Homocysteine is impaired due to the deficiency of B12. What does high Hyc do?

A

Elevated Hyc destroys the endothelial lining and damaged endothelial lining causes thrombi formation.

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9
Q

In B12 deficiency, Methionine levels are low or high?

A

Low

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10
Q

Folate is trapped in the cell in the form of?

A

N5-methyl-THF

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11
Q

B12 and Folate deficiencies both cause neurological symptoms.
True or False.

A

False

Only B12 deficiency does.

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12
Q

What test is done to evaluate B12 absorption?

A

Schilling’s Test

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13
Q

What is Achlorhydria?

A

Reduction of gastric acid secretions

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14
Q

Pernicious Anemia is caused by

A

Failure of the gastrointestinal tract to absorb B12

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15
Q

Lack of Intrinsic factor can be caused by

A

Gastrectomy of Parietal or Total tract.

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16
Q

Treatment of B12 deficiency

A

Oral supplementation of B12

Intramuscular injections of cyanocobalamin

17
Q

What are the levels of ALP in pernicious anemia?

A

Low levels of ALP

18
Q

Where is Vitamin B12 stored in our body?

A

Liver

19
Q

B12 is __________ (released/remain bonded) from food in the acidic environment of the stomach.

A

Released

20
Q

In the stomach, free B12 binds a glycoprotein ___________ (Haptocorrin/Intrinsic factor) and moves to the intestine.

A

Haptocorrin or R-protein

21
Q

When entered in intestine, pancreatic enzymes break the bond between R-protein and B12 and then B12 bonds to ___________ (Intrinsic factor/cubilin)

A

Intrinsic factor

Cubilin is the receptors present on cells of ileum.

22
Q

B12 when enters the general circulation it is transported by ____________ (transcobalamin/cubilin/albumin)

A

Transcobalamin

Vitamin (11 decks)

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