Lecture 61 - Penicillins

Question 1

Penicillins are bacterio____. They bind PBP, inhibiting the transpeptidase reaction.

Answer 1

Bacteriocidal

Question 2

Beta-lactams can be coupled with Beta-lactamase inhibitors (BLIs).

Amoxicillin + ______
Ticarcillin + ______
Ampicillin + ______
Piperacillin + ______

Just keep in mind some beta-lactamases cannot be inhibited by the BLIs.

Answer 2

Amoxicillin + Calvulinic acid

Ticarcillin + Calvulinic acid

Ampicillin + Sulbactam

Piperacillin + Tazobactam

Question 3

Penicillin interacts with oral _______, and can decrease their effectiveness. Also, ______ is a drug used to treat gout and competes with Penicillin for renal secretion –> higher serum penecillin bc not excreted.

Answer 3

Contraceptives

Probenacid

Question 4

Monobactams are ONLY effective against Gram ____ bacilli.

Answer 4

Gram -

Question 5

Imipenem, Doripenem, Meropenem, and Ertapenem are all _______. Which of the four is the only one inactivated by renal dehydropeptidases and what is given as an inhibitor of this renal enzyme?

Answer 5

Imipenem is inhibited by renal dehydropeptidase, and Cilastatin is given as an inhibitor of this enzyme.