L30- Antidiabetic Drugs II (TZDs)

Question 1

TZD = ____ + list the drugs

Answer 1

thiazolidinediones, aka glitazones

• pioglitazone
• rosiglitazone

Question 2

TZDs:

• mainly used to dec (1)
• agonist of (2) membrane receptors
• intracellular receptors in (3) cells

Answer 2

1- dec insulin resistance

2- PPAR-γ (perioxisome poliferator-activated receptor-γ)

3- muscle, fat, liver

Question 3

TZDs are alternatives to ______ antidiabetic drugs because they have the same end goal

Answer 3

• act to dec FPG, HbA1c

- less effective than sulfonylureas, metformin

Question 4

describe glitazone speed of onset

Answer 4

slow onset, may take wks to mos to change activity

Question 5

TZDs, indicate the preferred drug and why

Answer 5

-pioglitazone > rosiglitizone

better improvements in: HDL, TGs, LDL particle concentration, LDL particle size

Question 6

TZD AEs

Answer 6

-fluid retention, weight gain, edema

-exacerbated CHF
contraindicated in Class III/IV HF

Question 7

(1) was the first TZD, and was removed due to (2), causing a (3) effect for TZD use

Answer 7

1- troglitazone
2- severe hepatic toxicity
3- LFT monitoring