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dr taher classes HK > CVS 10 > Flashcards

CVS 10 Flashcards

1
Q

XLR disease mnemonic

A 
GOLF CHilD
G6PD
Otc def (orotic aciduria)
Lesch neyhan
Fabry (a galactosidase)
Hunter ( iduronolate)
CGD
D Alas (heme synthesis)
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2
Q

terbinafine mechanism

A

inhibits sq epoxidase

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3
Q

terbinafine used to treat

A

onychomycosis / dermatophyte

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4
Q

terbinafine S.E

A

toxic to liver

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5
Q

Echinocandins

A 
fungins 
cell wall ( b glucan)
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6
Q

echinocandins S.E

A

histamine release

GI upset

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7
Q

mechainsm of Griseofulcin

A

inhibits microtubules

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8
Q

method of administration of Griseofulvin
where does it have its major effect?
idications?

A

orally
keratin areas
tinea / ring worms

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9
Q

Griseofulvin cyp450 enzyme inhibitor or inducer

A

inducer

remmber My New GPRS Cell Phone

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10
Q

side effects of Griseofulvin

A

Disulfram like reactions

flushing tachy hpoTension

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11
Q

drugs that can cause a disulfram like reaction

A 
CGMP
Cefoperazone (3rd), cefotetan (2nd)/ chlorpropamide
Griseofulvin (microtubule)
Metronidazole
Procarbazine ( alkylating agent)
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12
Q

smallest form of cytoskeletal elements

and some examples

A

microfilaments

actin/ microvilli

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13
Q

viementin

A 
intermediate  filament
found in mesenchymal tissue
sarcoma 
RCC
meningioma
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14
Q

GFAP

A

intermediate filament

Glial cells

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15
Q

Desmin

A

intermediate filament
muscle (rhabdomyosarcoma)
ex Tuberous sclerosis

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16
Q

cytokeratin

A

also intermediate filament

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17
Q

largest cytoskeletal element

A

microtubule

movement / cell division

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18
Q

drugs MOA inhibiting microtubule polymerization

A

vincristine vinblastine

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19
Q

MOA inhibting de polymerization

A

paclitaxel

docitaxel

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20
Q

aneterograde transport

A

kinesis (towards +ve side)

Positive in Periphery

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21
Q

retrograde transport

A

dyenin

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22
Q

viruses that use retrograde transp

A

polio
herpes
rabies
tetanus

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23
Q

what is the DOC for herpetic neuralgia

A

gabapentin

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24
Q

drugs that inhibit microtubule formation

A

Griseofulvin
bendazoles
colchicine

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25
Q

Kartagener
mode of inheritnce
whats the defect
signs symp

A 
AR
dyenin arm 
primary ciliary dyskinesia
recurrent sinusitis/ situs invertus/ bronchiectasis
ectopic pregnancy
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26
Q

screening test for cystic fibrosis and primary ciliary dysk

A

nitric oxide test

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27
Q

what is required for synchronous contraction of heart uterus osteocytes etc

A

gap junction

28
Q

failure of phagosome to fuse with lysosome

A

chediak hegashi

29
Q

symp of chediak higashi

and the gene

A 
PLAIN 
Progressive neurodegeneration
Lymphohystiocytosis
Albinism
Neuropathy

gene LYST

30
Q

budding yeast at 20 degrees

germ tubes at 37

A

Candida

31
Q

Candida has true hyphae or pseudihyphae

A

both

pseudohyphae at germ tubes 37 degrees

32
Q

who is at risk for candida inf

A

babies
immunocomp
HIV
diabetics

33
Q

typical infection in baby linked to candida ?

and in females?

A

diaper rash

vulvovaginitis

34
Q

txt for candida

A

flucanazole
nystatin
fungins
ampho b

35
Q

branch septate hyphae at 45 degrees

V shape

A

aspergillus

36
Q

what is the form of aspergillus

A

MOLD form not dimorphic

37
Q

aspergilloma can be formed in what conditions

A

pre existing cavitary lesions in TB for exmp
air crescent sign
aflatoxin

38
Q

invasive aspergillosis

A

Neutrophils low
Immunocomp
HIV
CGD

39
Q

aflatoxin can cause

A

HCC

alcohol

40
Q

afltoxin found in

A

aspergillus
stored grains
nuts
causes HCC

41
Q

Arsenic

A

smelting of metals/ vineyards

angiosarcoma

42
Q

cigarette smoke

A 
has PAH 
lung cancer (sq, small cell, large cell)
bladder canc ( sq and transitional)
esophageal (adeno lower eso, sq upper 2/3 eso)
RCC
43
Q

relative vitamin A def caused by

A

cigarette smoke and it leads to
pancreatic cancer
cervical sq
laryngeal carcinoma

44
Q

aljylating agents can cause

A

leukemia and lymphoma

45
Q

Napthylamine

A

transitional cell carc

46
Q

HPV

A

16 18 31 33

cervical penil head and neck cancer

47
Q

HTLV 1

A

adult t cell leukemia/ lymphoma

48
Q

HTLV 1 belongs to whch virus class

A

retrovirus like HIV

49
Q

EBV herpes 4

A

hodgkin
non hodgkin
nasopharyngeal ca (chinese)
primary CNS lymphoma (<100 cd4)

50
Q

EBV in endemic areas can cause

A 
burkitt lymphoma
8,14 transloc
extranodal mass =
jaw (african)
abdomen (sporadic)
51
Q

EBV in transplant pt

A

lymphoprolif disease

52
Q

schistosoma hematobium

A

squamous cell carcinoma of bladder

53
Q

chlonorchis sinensis

A

liver fluke

cholangiocarcinoma

54
Q

H pylori

A

intestinal type gastric carcinoma

MALTOMA (11,18)

55
Q

inflammation MALTOMA can be caused by or seen in

A

H pylori
sjogern
hashimoto

56
Q

type 1 hypersensitivity response assoc with asthma Cystic Fibrosis
may cause bronchiectasis and eosinophilia

A

Allergic bronchopulomonary aspergillosis

57
Q

encapsulated yeast

pigeon droppings

A

cryptococcus neof

58
Q

dissemination route for cryptococcus

A

hematogenous spread

59
Q

cryptococcus meningitis appearance

A

soap bubble

60
Q

what is the special test for cryptococcus

also the ink?

A

latex particle agglutination

india ink

61
Q

how to stain the capsule for cryptococcus

A

mucicarmine stain

RED capsular inner core

62
Q

mold form only

broad 90 degrees non septate

A

mucor rhizophus

63
Q

how is mucor contracted

A

inhaled — prolif in bloooood vessels —- penetrate through cribriform plate and into inus

64
Q

most common cause of cavernous sinus thrombosis

A

STAPH AUR
strept
mucor

65
Q

drainage of cavernous sinus

A

sup petrosal sinus —- great verebral vein pf gallen

inf petrosal sinus —- int jugular vein

66
Q

3rd cranial nerve palsy

A

down n out

67
Q

corneal senation

A

V1 sensory

7 is motor (reflex)

dr taher classes HK (24 decks)

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