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dr taher classes HK > CVS 17 > Flashcards

CVS 17 Flashcards

1
Q

gastroenteritits in cruise ships and daycare

A

norovirus

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2
Q

calcivirus

A

norovirus ICOSAHEDRAL

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3
Q

RNA non enveloped virus

A 
CPRH
Calci
Picorna
Reo
Hep E
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4
Q

Picorna virus includes

A 
PERCH
Polio
Echo
Rhino
Cxsackie
Hep A
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5
Q

NON enveloped DNA

A 
PAPP
Parvo
Adeno
Papilloma
Polyoma
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6
Q

Corona virus

A

common cold SARS

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7
Q

Delta cirus

A

HEP D —- defective virus

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8
Q

how does hep b help hep D

A

helps hep D to invade and replicate
forms the EXTERNAL shell of HEP D
HBsAG forms the coat

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9
Q

two forms of infections by HEP D

A

co infection —- B + D together

Suprainfection — previosuly infected hepatocytes get inf with HEP B

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10
Q

mode of HEP D transmission

A

sexual
perinatal

R/O HCC

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11
Q

which hepatitis virus dont increase risk for HCC

A

HEP A and E

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12
Q

Hepatitis A belongs to

A

Picorna virus — RNA

feco oral route —- shell fish too

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13
Q

shell fish can be linked with

A

hep A
v. cholera
clostridium sepcticum

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14
Q

hep A incubation and risk factors

A 
short 30 days 
travellers 
overcrowded areas/ poor sanitation
endemic regions 
homosexual men
chronic liver disease 
clotting factor disorders
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15
Q

biopsy of hep A liver

A

swelling of hepatocytes
macrophages and lymphocytes (CD8 T cells)
councilman bodies — apoptotic bodies

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16
Q

vaccine for hep a

A

yess

also give immuniglobulins

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17
Q

special about HEP B

A

has a reverse trasncriptase activity

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18
Q

transcriptional activator made by hep B

A 
HBX 
it is a viral protein 
interferes with p53 function
activates synthesis of IGF 1 receptor (proliferation)
and insulin like growth factor 2
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19
Q

early onset of hep b symtoms

A

fever
arthralgia
rash
SERUM SICKNESS

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20
Q

syndromes tha tcan be cuased by HEP B

A

acute Hep b —- cn resolve
chronic hepatitis — with / without cirrhosis
massive liver necrosis —- fulminant hepatitis

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21
Q

Hbs ag

A

acute infection

chronic infection with inc infectivity and also with decreased infectivity

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22
Q

Hbs AB

A

immunized

recovery

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23
Q

HBe ag

A

acute

chronic high infectivity

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24
Q

HBe ab

A

recovery
WINDOW
chronic LOW infectivity

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25
Q

HB c Ab

A

recovery

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26
Q

marker of Hep B infection

A

surface antigen

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27
Q

mother has active hep B

what will be seen in the neonates blood

A

HB e ag
INC viral load
can cross placenta

these babies are mostly asymptomatic —- can progress to cirrhosis and HCC

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28
Q

txt for neonates with hepb mothers

A

vaccine can be given
immunoglobulins can be given tooo
PREVENT CHRONIC INFECTION

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29
Q

biopsy of hep B

A

T CELL CD 8 mediated apoptosis — ag is presented on teh suface of hepatocytes MHC 1
ground glass app

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30
Q

hep B itself has no cytotoxic effect

what has this effect

A

surface antigen

core antigen

31
Q

chronic viral hepatitis inflammation

A

mainly targets surrounding area of portal triad
hepatic artery
portal vein
bile ducts

32
Q

how to reduce worldwide cases of HCC

A

HEP B VACCINE

33
Q

lacks 3’5 exonuclease activity

A

HEP C
proof reading activity — HC e Ag

this is why no vaccine —- antigenic variation cause envelope antigen is always changing

34
Q

biopsy of hep c shows

A

macrovesicular STEATOSIS
lymphoid aggregates portal tracts
PATCHY necrosis

35
Q

Hepatitis E

A

non enveloped

fulminant hepatitis in pregnant mothers

36
Q

inflammation of LIVER parenchyma can be caused by

A

EBV
CMV
HEP

37
Q

Flavivirus

A 
HCV
dengue
yellow
st louis encephalitis
west nile virus
zika virus
38
Q

dengue fever symptoms

A 
flu like illness 
myalgia 
joint pain (break bone fever)
RETRO ORBITAL PAIN
rash ------ white island in sea of red
39
Q

All RNA are single straded EXCEPT

A

REO virus
colitivirus —- colarado tick fever
rotavirus —- fatal diarrhea

40
Q

All DNA are double stranded EXCEPT

A

parvo —- single stranded

41
Q

Dengue hemorrhagic fever

A 
thrombocytopenia 
increased vascular permeabillity 
increase risk of bleeding
SHOCK
hypotension
42
Q

secondary infection of dengue

A

usually by a diffff serotype

much more severe course of disease

43
Q

diagnosis of dengue

A

torniquet test — cuff inflammation for 5 mins —– PETECHIA

NS1 antigen

44
Q

simultaneous infections with dengue

A

CHIKUNGUNYA

ZIKA

45
Q

West nile virus grows mostly in

A

birds and warm climate

46
Q

west nile transmission

A

aedes mosquito

47
Q

west nile mannifestation

A

myalgia
headache

progress — meningitis / encephalitis
neurological deficits
flaccid paralysis

neurological deficits can be lethal — stay LONG TERM

48
Q

developing countries — flaccid paralysis makes u think of

A

polio

49
Q

which viral infection can show parkinson like features too

A

west nile

50
Q

arbovirus vector transmits

A

west nile ( flavi)
la cross virus
east/west equine (toga)
st. louis encephalopathy (flavi)

51
Q

risk factors that lead to west nile infection

A

malignancy
immune supp
elderly

52
Q

CSF analysis in West nile virus

A

lymphocytic pleocytosis

53
Q

YEllow fever reservoir

A

monkeys

flavivirus

54
Q

mannifestation of flavi

A

black vomitus
jaundice
destructive apoptotic bodies —- councilman bodies

55
Q

zika virus

A

flavivirus
infects FETAL NEURAL PROGENITOR cells

severe congenital malformations — microencephaly, miscarriages, congenital contractures joint
cortical thinning

56
Q

transmission, diag and txt for zika

A

sexual / vertical tx
diag —- RT PCR
no txt —- lethal

57
Q

filo virus

A

EBOLA
targets ENDOTHELIAL cells!!
Liver —- incubation for 3 weeks

58
Q

sympmtoms of ebola

A 
flu like 
myalgia 
fever
vomitting 
hemorrhagic shock 
DIC

reservoir – monkey, body fluids

59
Q

how to protect onself from ebola in healthcare env

A

strict isolation of infected

60
Q

Picorna virus

A 
PERCH
Polio
Echo 
Rhino
Coxsackie
Hep A
61
Q

Polio

A

ant horn — LMN symptoms

62
Q

what type of polio vaccines are there

A

LIVE —– sabin — oral

KILLED —- salk —-

63
Q

anterior horn can be affected in which conditions

A

polio
West nile virus (flavi)
werdng hoffman synd
spinal muscular dystrophy

64
Q

Live vaccinations examples

A 
strong life long immunity
Polio
Rotavirus
MMR
VZV
yellow fever 
influenza (intranasal)
small pox
typhoid
BCG
adenovirus
65
Q

which live vaccine can be givin in HIV pts

A

> 200 CD4

MMR and varicella

66
Q

killed vaccine

A 
RIPA
Rabies
Influenza (IM)
Polio ( SALK)
AHEP A
67
Q

what kind of resp induced by killed vac

A

humoral only
ag is present on the extracellular surface so cant elicit a t cell resp

prevents viral entry inside cell so cant be presented by APC —- need boosters

68
Q

sub unit vaccines

A 
Ag   Hbs Ag
HPV (high risk)
Str pneumo
Nisseria
H. influenza
69
Q

conjugate vaccine

A

polysaccharide PLUS PROTEIN — stronger resposne (T CELL)

H.inf
N,meningitidis
str pneumo

70
Q

toxoid vaccine

A

diptheria
tetanus
whooping cough

71
Q

what is a toxoid vaccine

A

denatured toxin pf bacteria BUT INTACT receptor that can bind to antibodies

72
Q

echovirus

A

from picronavirus

cause aseptic meningitis

73
Q

coxsackie virus

A

picornavirus

dr taher classes HK (24 decks)

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