[SGD Recalls] - Vitamin B12 Deficiency

Question 1

Release Vit from protein binding food 
A. Gastric
B. Pepsin 
C. Gastric and pepsin   
D.  NOTA

Answer 1

C. Gastrin and pepsin

Question 2

Present in saliva that binds B12 
A. Transcobalamin I 
B. Transcobalamin II 
C. Cobalophilin   
D. IF

Answer 2

C. Cobalophilin

Question 3

After reaching the stomach it binds to 
A.Transcobalamin  I 
B.Transcobalamin  II 
C. Cobalophilin  
D. IF

Answer 3

D. IF

Question 4

Bind into this that transports it to the liver

A.Transcobalamin I
B.Transcobalamin II
C. Cobalophilin
D. IF

Answer 4

A.Transcobalamin I

Question 5

Secreted by parietal cells in gastric mucosa

A. Transcobalamin I
B. Transcobalamin II
C. Cobalophilin
D. IF

Answer 5

D. IF

Question 6

Site of absorption of B12

A. Duodenum
B. Stomach
C. Jejunum
D. Ileum

Answer 6

D. Ileum

Question 7

Most potent test to use in determining B12

A. MMA test
B. PBS
C. Folate level

Answer 7

A. MMA test

Question 8

An enzyme in which the B12 is the cofactor of it for the conversion of MMA to Succinyl Coa
A. Methionine Synthase
B. Succinyl Coa mutase
C. Methyl Malonic CoA mutase

Answer 8

C. Methyl Malonic CoA mutase

Question 9

Plasma protein-binding

Answer 9

Ans: TRANSCOBALAMIN II

Question 10

What is the common cause of pernicious anemia?

Answer 10

Ans: Failure of the absorption of Vit. B12

Question 11

Which of the following are Vit. B12 dependent, EXCEPT?

a. Methyl malonyl coA
b. Leucine aminomutase
c. Methyl aminomutase
d. Methionine synthase

Answer 11

c. Methyl aminomutase

Question 12

What secretes IF?

Answer 12

Ans: Parietal cells in gastric mucosa

Question 13

Is a free Intrinsic Factor or free Vit. B12 absorbed in ileum?

TRUE
FALSE

Answer 13

FALSE

Question 14

If there is pancreatic insufficiency what causes Vit. B12 deficiency?

Answer 14

Ans: Prevents hydrolysis of TCNI in duodenum

Question 15

What reaction leads to Vit. B12?

Answer 15

Ans: Methyltetrahydrofolate to THF

Question 16

What enzyme is responsible for the conversion of methionine from homocysteine?

Answer 16

Ans: Methylcobalamin

Question 17

What is the cofactor for Methylmalonyl CoA to Succinyl CoA isomerization?

Answer 17

Ans: Adenosyl cobalamin

Question 18

What is the specific test for Vit. B12 deficiency?

Answer 18

Ans: Methyl Malonic Acid Test (MMA)

Question 19

What characteristic erythrocyte feature is seen among patients with Vitamin B12 deficiency?

a. Hypochromic, normocytic RBC
b. Hypochromic, microcytic RBC
c. Hyperchromic, normocytic RBC
d. Hypochromic, macrocytic RBC

Answer 19

d. Hypochromic, macrocytic RBC

Question 20

In Vitamin B12 absorption, the vitamin is released from protein binding in food by:

a. pepsin
b. cobalophilin
c. gastric acid and cobalophilin
d. gastric acid and pepsin

Answer 20

d. gastric acid and pepsin

Question 21

True of Vitamin B12 except:

a. derived from animal source
b. requires a glycoprotein for absorption
c. cofactor form is methylcobalamin
d. cofactor form is deoxycobalamin

Answer 21

b. requires a glycoprotein for absorption?

Question 22

What is the specific transport protein of Vit. B12 to plasma?

a. Transcobalamin I
b. Transcobalamin II
c. Cobalophilin
d. Intrinsic Factor

Answer 22

b. Transcobalamin II

Question 23

What test can be used to confirm malabsorption of Vit. B12?

a. Sickle Test
b. Ferritin Test
c. Spectrin Test
d. Schilling Test

Answer 23

d. Schilling Test

Question 24

More specific test for diagnosis?

Answer 24

Ans. Methylmalonate test (MMA)

Question 25

Glycoprotein secreted by salivary and gastric glands that carries free cobalamin

Answer 25

Ans. Haptocorrin (R protein)

Question 26

Best method for cobalamin administration

Answer 26

Ans. Parenteral route