Genomes

Question 1

What are the goals of the HGP?

Answer 1

• To sequence the human genome
• To identify genes and their functions
• To investigate the associations between genes and disease

Question 2

How many genes in the human genome?

What % of these are coding ones?

Answer 2

21,000

1.6%

Question 3

Give the name of some sequences in DNA

Answer 3

Introns
Protein-coding regions
Non-repetitive and non coding DNA
Repeated sequences (LINES and SINES - long and short interspersed elements)

Question 4

What is bioinformatics?

Answer 4

Using computers to analyse and organise genome data

Question 5

What does comparison of known genes help us to do?

What does comparison of predicted amino acid sequence and 3D structures help us to do?

Answer 5

To identify genes and suggest functions

Helps assign proteins to functional families

Question 6

What other ‘omes’ are we now studying?

Answer 6

The transcriptome
The proteome
The microbiome

Question 7

What are common differences between organisms called?

Answer 7

Polymorphisms

Question 8

What is the most common type of human polymorphism?

Answer 8

Single nucleotide polymorphisms

Question 9

Which feature of the human genome is derived from insertion of retro virus genomes?

Answer 9

LINEs (long intersperses elements)