CLINICAL PHARMACOLOGY

Question 1

Paracetomol overdose leads to 1)___ and 2)___ damage.
It is because of 3)___, leading to 4)__, hence producing 5)__.
5) is converted to 6)__ by 7)__, which when saturated leads to 8)__.
Drug of choice is 9)__ because it is 10)__.

Answer 1

1) liver
2) renal tubule
3) glucorunic acid/sulphate conjugation system saturation
4) oxidation by P450 mixed function oxidases
5) toxic metabolite (N-acetyl-B-benzoquinone imine)
6) mercapturic acid (non toxic)
7) Glutathione conjugation system
8) Toxins forming covalent bonds with proteins, denature gets them and causing cell death
9) NAC
10) Precursor of Glutathione

Question 2

Glycaemic Control in DM is worsened by _____

Answer 2

Drugs causing IGT:-

Steroid
Tacrolimus/Ciclosporin
Antipsychotic
IFN-y
Nicotine acid
Thiazides/Loop Diuretics