Week 4 HNN Lectures

Question 1

What is an agonist?

Answer 1

Activates a receptor and produces a functional response in the cell

Question 2

What is an antagonist?

Answer 2

binds to the receptor without activating it, blocking agonists (including endogenous agonists)

Question 3

What is a partial agonist?

Answer 3

partially activates a receptor, producing a smaller functional response in the cell

Question 4

What are the main routes of administration of drugs of the CNS?

Answer 4

Enteral, Parenteral, Intrathecal

Question 5

What type of drugs are enteral?

Answer 5

Lipophilic

Question 6

What are the functions of the blood brain barrier?

Answer 6

Maintaining a constant environment
protecting the brain from foreign substances
protecting the brain from peripheral transmitters

Question 7

What are diseases associated with compromised BBB?

Answer 7

Hypertension, Infection/ inflammation and trauma

Question 8

What is GLUT1 responsible for?

Answer 8

Glucose transport across the blood brain barrier

Question 9

What is GABA?

Answer 9

Gamma-Aminobutyric Acid

Question 10

What is the effect of GABA?

Answer 10

Has an effect on chloride channels - increases influx

Question 11

How does GABA have its effect?

Answer 11

Inhibits cell firing

Question 12

What is glutamate?

Answer 12

One step back from GABA

Question 13

What does glutamate do?

Answer 13

Activates Na and Ca channels

Question 14

How does glutamate have its effect?

Answer 14

Promotes cell firing