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VET 375 > Lecture 11 > Flashcards

Lecture 11 Flashcards

1
Q

What are some reasons as to why soluble mediators are important in the acute inflammation?

A
  1. they act as switches the will turn inflammatory responses on an off 2. messengers- they are able to control actions of the cell 3. stimulate pain
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2
Q

What are the three different origins of soluble mediators?

A

CELLULAR: - preformed mediators in secretory granules - newly synthesised granules PLASMA: - contributes to the blood

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3
Q

Fill out the blanks on the diagram below:

A
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4
Q

What are the four main systems that are activated by the Hageman factor?

A
  1. Kinin cascade
  2. Clotting system
  3. Fibrinolytic system.
  4. Complement system
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5
Q

What is the main link between the coagulation system and inflammation?

A

Thrombin

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6
Q

What is the function of bradykinin within the kinin cascade?

A
  1. Increases vascular permeability
  2. Contraction of smooth muscle
  3. Dilation of blood vessels
  4. Pain
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7
Q

What is the function of fibrin within the clotting cascade?

A
  1. Increases wbc adhesion
  2. Scaffold for wbc
  3. “glue” to trap foreign agents
  4. fibroblast proliferation
  5. collagen production
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8
Q

What is the function of fibrin degradation products?

A
  1. Increased vascular permeability
  2. Increased leukocytes in exudates
  3. Increased chemotaxis (esp. neutrophils)
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9
Q

Breifly describe the major products that are produced within the complement cascade an the effect of them:

A
  1. C3B goes to C5a and C3a
  2. C5a and C3a cause inflammation
  3. C3b leads to phagocytosis
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10
Q

What is the effect of the cell derived mediator histamine and serotonin?

A
  1. Arteriolar vasodilation
  2. Extravascular small muscle contraction
  3. Increased permeability
  4. Pain
  5. Chemoattractant for eosinophils (histamine)
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11
Q

When is histamine released by mast cells?

A
  1. Physical injury
  2. Immune reactions
  3. Fragments of complement proteins
  4. Histamine releasing proteins.
  5. Neuropeptides
  6. Cytokines
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12
Q

What is the inhibitory of effect of steroid drugs?

A

Inhibit phospholipases

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13
Q

What is the effect of non-steroidal drugs?

A

Inhibits Cyclooxygenase

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14
Q

What is the effect of lipoxins?

A
  1. inhibit leukocyte recruitement, neutrophil chemotaxis, neutrophil adhesion
  2. negative regulators of LT’s
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15
Q

What is the effect of resolvins?

A
  1. Inhibit leukocyte recruitement
  2. Inhibit leukocyte activation
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16
Q

What are the major actions of cytokins?

A
  • Endothelial activation
  • Leukocyte activation
  • Fibroblast recruitment
  • Priming of neutrophils
  • Differentiation of lymphocyte subsets

VET 375 (30 decks)

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